Monoallelic characteristic-bearing heterozygous L1053X in BRCA2 gene among Sudanese women with breast cancer

BMC Medical Genetics

Table 6 The geographic provenience of the samples previously detected with the mutation L1053X

SAMPLE geographic provenience	L1053X mutation frequency	Type	Cases	Age	The study highlighted the mutation	Sample source
Canada, USA and Poland^*1	1 family (not specified)	Germline	Familial BC	-	Lubinski, et al. 2004 [18]	Research centers
UK, USA^*2	1 control subject (not specified)		-	54	Song H, et al. 2014 [40]	Gayther SA, et al. 2007 [54]
Australia	1 case; as HRM High Resolution Melting Method validation	Method validation	Not specified	-	Hondow HL, et al. 2011 [53]	Peter MacCallum Cancer Centre and the Kathleen Cunningham Foundation Consortium for Research into Familial Breast Cancer (kConFab)
UK, Netherlands^*3	1 case	Germline	Prostate ca	54.6	Sandhu SK, et al. 2013 [39]	Fong PC, et al. 2009 [55]
UK	1 case	Germline	Prostate ca with family history of BC and Lung ca	46	Kote-Jarai Z, et al. 2011 [38]	Eeles RA, et al.1997 [56]

^*1Cancer centres where the sampling protocols including family pedigree were performed
^*2based on large population studies: the population-based SEARCH study UK and the hospital-based Mayo clinic study from USA
^*3The centers where the study was performed: at the Royal Marsden National Health Service (NHS) Foundation Trust (United Kingdom) and the Netherlands Cancer Institute (the Netherlands)

ISSN: 1471-2350