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Table 2 Allele counts (frequencies) of CNV at TRB in PsA patients and controls (Ctrl)

From: Genome-wide association and targeted analysis of copy number variants with psoriatic arthritis in German patients

part of study

n (%) –risk allele in PsA

n (%) –non-risk allele in PsA

n (%) –risk allele in Ctrl

n (%) – non-risk allele in Ctrl

P-value

OR [95% CI]

discoverya

776 (81.2)

180 (18.8)*

5288 (69.6)

2308 (30.4)*

1.22 × 10−13

1.88 [1.59–2.23]

extended PsA, independent Ctrl cohort

801 (51.1)

765 (48.9)*

947 (52.8)

847 (47.2)*

0.34

0.94 [0.82–1.07]

  1. Deletion is marked by *. The p-value corresponds to a χ2 test of of 478 patients and 3798 control individuals. Odds ratio [95% confidence interval] for the discovery study (array-based analysis) were calculated for the same cohorts. The replication cohort (MLPA-based results) was partially overlapping for PsA, and consisted of 782 patients and 897 controls. aDiscovery describes the initial SNP array-based analysis with the filter criteria of 5 markers and 5 kb before validation with MLPA