Table 5 Allele and genotype frequencies in HT patients with hypothyroidism or euthyroidism and controls
GENE | SNP | Alleles | Con (%) | HT-hypo (%) | P | HT-eu (%) | P | P (Eu/hypo) |
|---|---|---|---|---|---|---|---|---|
SEPS1 | rs28665122 | C | 1688 (93.47) | 344 (95.56) | 0.183 | 204 (93.58) | 0.914 | 0.335 |
T | 118 (6.53) | 16 (4.44) | 14 (6.42) | |||||
CC | 793 (87.82) | 165 (91.67) | 97 (88.99) | |||||
CT | 102 (11.3) | 14 (7.78) | 10 (9.17) | |||||
TT | 8 (0.9) | 1 (0.55) | 2 (1.84) | |||||
rs7178239 | G | 802 (45.57) | 148 (42.05) | 0.204 | 90 (42.86) | 0.414 | 0.860 | |
C | 958 (54.43) | 204 (57.95) | 120 (57.14) | |||||
GG | 180 (20.45) | 32 (18.18) | 22 (20.95) | |||||
CG | 442 (50.23) | 84 (47.73) | 46 (43.80) | |||||
CC | 258 (29.32) | 60 (34.09) | 37 (35.25) | |||||
Sepp1 | rs6865453 | A | 1338 (74.5) | 271 (75.70) | 0.585 | 158 (73.83) | 0.853 | 0.619 |
C | 458 (25.5) | 87 (24.30) | 56 (26.17) | |||||
AA | 491 (54.68) | 99 (55.31) | 54 (50.47) | |||||
AC | 356 (39.64) | 73 (40.78) | 50 (46.73) | |||||
CC | 51 (5.68) | 7 (3.91) | 3 (2.80) | |||||
GPX4 | rs713041 | C | 1031 (57.41) | 208 (58.10) | 0.694 | 117 (54.67) | 0.500 | 0.433 |
T | 765 (42.59) | 150 (41.90) | 97 (45.33) | |||||
CC | 300 (33.41) | 59 (32.96) | 29 (27.10) | |||||
CT | 431 (48) | 90 (50.28) | 59 (55.14) | |||||
TT | 167 (18.6) | 30 (16.76) | 19 (17.76) | |||||
rs2074451 | G | 1004 (55.96) | 200 (56.50) | 0.725 | 110 (52.38) | 0.401 | 0.381 | |
T | 790 (44.04) | 154 (43.50) | 100 (47.62) | |||||
GG | 292 (31.44) | 53 (29.94) | 25 (23.81) | |||||
GT | 440 (49.05) | 94 (53.11) | 60 (57.14) | |||||
TT | 175 (19.51) | 30 (16.95) | 20 (19.05) | |||||
rs3746165 | C | 1019 (56.74) | 204 (56.98) | 0.816 | 114 (53.27) | 0.399 | 0.434 | |
T | 777 (43.26) | 154 (43.02) | 100 (46.73) | |||||
CC | 287 (31.96) | 55 (30.73) | 26 (24.30) | |||||
CT | 445 (49.55) | 94 (52.51) | 62 (57.94) | |||||
TT | 166 (18.49) | 30 (16.76) | 19 (17.76) |