Fig. 3From: A case report of novel mutation in PRF1 gene, which causes familial autosomal recessive hemophagocytic lymphohistiocytosisComparative amino acids alignment of perforin protein across all Kingdoms. The W374 residue is highly conserved during evolution. The conserved tryptophan residue is shown in the rectangular box. Protein sequences were obtained from National Center for Biotechnology (NCBI). Symbols: (*)—identical amino acids; (:) — just similar amino acidsBack to article page