Fig. 6

Biophysical properties of currents from HEK-293 cells transfected with WT and TRPM4 variants. a Representative current tracings recorded in the whole-cell configuration (ramp protocol under the traces) (b) Mean current densities for WT and variants estimated using the maximal current recorded during the ending step of 20 ms at Vm = +100 mV (see a). c Rectification factor estimated by the current amplitude at +100 mV divided by the current amplitude at −60 mV . *p < 0.05, Error bar: standard error of the mean. Number of experiments is indicated in bars. Abbreviations: NT: Non-Transfected; WT: Wild-type