From: Autism spectrum disorder associated with 49,XYYYY: case report and review of the literature
• No response to his name by 12 months of age • No pointing at objects to show interest by 14 months of age • Difficulties understanding other people’s feelings (Theory of Mind disability) • Delayed speech and language skills • Extreme reactivity to minor changes • Restrictive and repetitive interests and stereotypies • Lack of interest in sharing with others • Inappropriate and poor facial expressions • Misunderstanding of personal space boundaries • Avoidance or resistance to physical contact • Unusual emotional reactions |