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Table 3 Genotypic class specific mean values for top SNPs from genome-wide association analyses of renal urate excretion measures

From: Genetic variation underlying renal uric acid excretion in Hispanic children: the Viva La Familia Study

SNP

Trait

Chr

Major/Major

Major/Minor

Minor/Minor

Direction of Changea

rs2033711

UACl

19

2.17 ± 1.79

2.79 ± 2.19

3.48 ± 2.69

↑

rs10908521

UACl

1

2.86 ± 2.28

2.06 ± 1.66

1.86 ± 1.34

↓

rs10423138

UACl

19

2.18 ± 1.78

2.77 ± 2.17

3.38 ± 2.68

↑

rs9874872

UrUA/UrCr

3

0.18 ± 0.12

0.13 ± 0.10

0.11 ± 0.08

↓

rs1353327

UrUA/UrCr

3

0.17 ± 0.11

0.11 ± 0.09

0.14 ± 0.13

↓

rs17079585

CrCl

13

54.26 ± 32.25

22.47 ± 14.47

-

↓

rs4889855

FEUA

17

7.22 ± 6.01

5.88 ± 5.74

4.34 ± 3.76

↓

rs17079585

GLUA

13

3.02 ± 2.28

1.28 ± 0.77

-

↓

  1. aDirection of associations for minor alleles of the SNPs in the genes associated with renal handling measures from GWAS; Chr chromosome, UACl uric acid clearance, UrUA/UrCr urinary uric acid to urinary creatinine ratio, CrCl creatinine clearance, FEUA fractional excretion of uric acid, GLUA glomerular load of uric acid