Skip to main content
Fig. 3 | BMC Medical Genetics

Fig. 3

From: A novel ANO3 variant identified in a 53-year-old woman presenting with hyperkinetic dysarthria, blepharospasm, hyperkinesias, and complex motor tics

Fig. 3

Annotated multiple sequence alignments (MSA) for ANO3 homologs and human ANO3 paralogs. a ANO3 homologs show a high degree of conservation across species (only select species shown; coloring by amino acid type). The site is either C or S from human, through hominids, rodents, and whales (shown by conservation and consensus logo) across 69 different species (identified by pBLAST [21] and aligned using COBALT [22]; data not shown). b Human ANO3 paralogs show some level of conservation in the region preceding the variant of interest (p.C234W; shown as a red box), but the site itself is not conserved across human paralogs. Both figures were created using Jalview [23]

Back to article page