Effect of Pregnane X Receptor*1B genetic polymorphisms on postoperative analgesia with fentanyl in Chinese patients undergoing gynecological surgery

Table 3 Effect of PXR ^* 1B haplotypes on postoperative analgesia

	Non-PXR ^* 1B	PXR ^* 1B	PXR ^* 1B/ ^* 1B	P value
Initial postoperative VAS scores	6.1 ± 1.3	6.2 ± 1.1	5.9 ± 1.0	0.414
Mean VAS scores during first 24 h	2.1 ± 0.7	2.3 ± 0.8	2.2 ± 0.8	0.601
Fentanyl consumption during first 24 h (μg)	468 ± 83	453 ± 85	435 ± 87	0.062
^bCYP3A activity (1′-OHMDZ:MDZ)	0.40 ± 0.12	0.39 ± 0.14	0.40 ± 0.11	0.885

Data are expressed as mean ± SD. Statistical significance was set at P < 0.05. P values are adjusted by age, sex, weight, remifentanyl dose during the operation, and type of surgery. ^bCYP3A4 activity (n = 95)

ISSN: 1471-2350