TAS2R38 taste receptor gene and chronic rhinosinusitis: new data from an Italian population

BMC Medical Genetics

Table 3 Observed distribution of genotypes at the TAS2R38 locus and CRS comorbidities (asthma, allergy, ASA sensitivity) or number of endoscopic surgical procedures in CRS patients, used for association analysis

	Asthma		Allergy		ASA sensitivity		N. surgeries		Tot.
	Present	Absent	Present	Absent	Present	Absent	1	>1	Tot.
PAV/PAV	6	2	3	5	2	6	4	4	8
PAV/-	18	14	19	13	9	23	10	22	32
−/−	6	7	7	6	1	12	5	8	13
Tot.	30	23	29	24	12	41	19	34	53

The following Π values were used to calculate the expected frequencies of each comorbidity (see Table 2): Π_{(Absence of asthma)} = 23/53 = 0.434; Π_{(Absence of allergy)} = 24/53 = 0.453; Π_{(Absence of ASA sensitivity)} = 41/53 = 0.774; Π_{(1 surgery)} = 19/53 = 0.358
Association between genotypes at the TAS2R38 locus and CRS aggravating factors was then tested by χ ²

ISSN: 1471-2350