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Fig. 2 | BMC Medical Genetics

Fig. 2

From: Placental DNA methylation at term reflects maternal serum levels of INHA and FN1, but not PAPPA, early in pregnancy

Fig. 2

Correlation between placental DNAm and gene expression at term in control samples and between placental DNAm and maternal blood protein levels during gestation in control samples. The correlation between DNAm at a regulatory element and gene expression (log2) in eight early-onset PE and eight control placentae in a INHBA b PAPPA and c FN1 † All gene expression graphs were produced from data published in Blair et al. (2013). The relationship between d INHBA (N = 36) promoter DNAm in the term placenta and second trimester INHA levels in maternal blood, plotted as residuals corrected for fetal birth weight (SD) and fetal: placental ratio, e PAPPA (N = 34) promoter DNAm in the term placenta and first trimester PAPPA levels in maternal blood, and f FN1(N = 76) enhancer DNAm in the term placenta and second/third trimester FN1 levels in maternal blood, plotted as residuals corrected for fetal birth weight (SD), gestational age, and maternal body mass index (BMI). MoM = multiple of the median

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