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Table 6 Correlation between cell count and cytokine and chemokine levels in CSF from BM patients in terms of genotypic combinations

From: Genetic polymorphisms associated with the inflammatory response in bacterial meningitis

Genotypic combinations

Cytokines and chemokines

   

APEX1 + 148 Asn/Asn plus IL8 -251 AA

IL-1β

IL-6

TNF-α

MIP1-α

MIP1-β

MCP-1

G-CSF

Spearman r

0.428

0.305

0.391

0.204

0.422

−0.155

−0.037

P-value

0.047*

0.168

0.072

0.363

0.050*

0.490

0.870

APEX1 + 48Glu/_ plus IL8 -251 T/_

IL-1β

IL-6

TNF-α

MIP1-α

MIP1-β

MCP-1

G-CSF

Spearman r

0.830

0.547

0.781

0.735

0.791

0.346

0.788

P-value

<0.001*

0.019*

0.0013*

<0.001*

<0.001*

0.159

<0.001*

APEX1 + 148 Asn/Asn plus AADAT + 401 CC

IL-1β

IL-6

TNF-α

MIP1-α

MIP1-β

MCP-1

G-CSF

Spearman r

0.111

0.506

0.311

−0.100

0.032

−0.007

−0.104

P-value

0.673

0.038*

0.224

0.701

0.903

0.978

0.691

APEX1 + 148 Glu/_ plus AADAT +401 T/_

IL-1β

IL-6

TNF-α

MIP1-α

MIP1-β

MCP-1

G-CSF

Spearman r

0.783

0.623

0.579

0.507

0.645

0.060

0.625

P-value

<0.001*

0.007*

0.005*

0.012*

0.005*

0.818

0.007*

  1. *Significant P-value (P < 0.05). Correlation analysis was performed using a two-tailed Spearman test (cell count vs. cytokine or chemokine levels)
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BMC Medical Genetics

ISSN: 1471-2350

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