BMC Medical Genetics

Table 5 Empirical power estimates for scenario 2 when h² is 0.2. The empirical power estimates for scenario 2 were calculated with 1000 replicates at the both 0.01, and 0.001 significance levels. The disease allele frequency was assumed to be 0.2, and the prevalence was assumed to 0.2. The relative phenotypic variance attributable to the main disease gene was assumed to be 0.005

From: Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families

	n _proband	Statistic	N
	n _proband	Statistic	100	300	600	900
0.01	1	WL	0.072	0.149	0.304	0.409
		FQLS ₁	0.072	0.147	0.305	0.415
		FQLS ₂	0.075	0.158	0.312	0.434
	2	WL	0.042	0.137	0.300	0.448
		FQLS ₁	0.039	0.136	0.303	0.455
		FQLS ₂	0.041	0.139	0.295	0.471
	3	WL	0.058	0.188	0.410	0.608
		FQLS ₁	0.054	0.191	0.424	0.620
		FQLS ₂	0.055	0.190	0.423	0.615
0.001	1	WL	0.025	0.059	0.147	0.211
		FQLS ₁	0.023	0.062	0.152	0.197
		FQLS ₂	0.022	0.055	0.152	0.212
	2	WL	0.010	0.038	0.123	0.229
		FQLS ₁	0.012	0.036	0.123	0.232
		FQLS ₂	0.010	0.036	0.127	0.227
	3	WL	0.006	0.055	0.182	0.342
		FQLS ₁	0.007	0.055	0.182	0.355
		FQLS ₂	0.009	0.057	0.182	0.356

The bold text indicates the highest empirical estimate of the power for each situation

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