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Table 3 Empirical power estimates for scenario 1 when h2 is 0.5. The empirical power estimates for scenario 1 were calculated with 1000 replicates at the both 0.1 and 0.001 significance levels. The disease allele frequency was assumed to be 0.2, and the prevalence was assumed to 0.2. The relative phenotypic variance attributable to the main disease gene was assumed to be 0.005

From: Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families

 

n proband

Statistic

N

100

300

600

900

1200

1400

0.01

1

WL

0.052

0.142

0.369

0.518

0.682

0.765

FQLS 1

0.053

0.145

0.352

0.523

0.681

0.766

FQLS 2

0.056

0.151

0.389

0.543

0.702

0.796

2

WL

0.053

0.174

0.396

0.616

0.761

0.829

FQLS 1

0.054

0.183

0.400

0.619

0.780

0.834

FQLS 2

0.053

0.202

0.422

0.658

0.799

0.859

3

WL

0.068

0.118

0.470

0.692

0.808

0.818

FQLS 1

0.073

0.216

0.489

0.705

0.826

0.905

FQLS 2

0.067

0.232

0.498

0.729

0.826

0.904

4

WL

0.066

0.222

0.528

0.755

0.860

0.938

FQLS 1

0.068

0.250

0.560

0.774

0.882

0.939

FQLS 2

0.072

0.244

0.544

0.766

0.870

0.935

0.001

1

WL

0.012

0.034

0.143

0.247

0.376

0.505

FQLS 1

0.015

0.046

0.142

0.245

0.387

0.496

FQLS 2

0.013

0.046

0.169

0.305

0.442

0.567

2

WL

0.008

0.060

0.151

0.342

0.494

0.612

FQLS 1

0.014

0.055

0.163

0.357

0.512

0.640

FQLS 2

0.012

0.055

0.184

0.378

0.538

0.648

3

WL

0.005

0.033

0.223

0.404

0.579

0.595

FQLS 1

0.008

0.076

0.235

0.432

0.604

0.717

FQLS 2

0.010

0.078

0.236

0.438

0.610

0.699

4

WL

0.010

0.079

0.274

0.484

0.655

0.763

FQLS 1

0.008

0.088

0.296

0.490

0.677

0.783

FQLS 2

0.014

0.084

0.280

0.474

0.671

0.769

  1. The bold text indicates the highest empirical estimate of the power for each situation