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Table 2 Empirical power estimates for scenario 1 when h2 is 0.2. The empirical power estimates for scenario 1 were calculated with 1000 replicates at the both 0.01 and 0.001 significance levels. The disease allele frequency was assumed to be 0.2, and the prevalence was assumed to 0.2. The relative phenotypic variance attributable to the main disease gene was assumed to be 0.005

From: Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families

 

n proband

Statistic

N

100

300

600

900

1200

1400

0.01

1

WL

0.027

0.062

0.129

0.219

0.293

0.369

FQLS 1

0.029

0.064

0.122

0.220

0.304

0.372

FQLS 2

0.029

0.059

0.129

0.230

0.306

0.385

2

WL

0.033

0.076

0.165

0.295

0.415

0.456

FQLS 1

0.036

0.073

0.166

0.309

0.418

0.461

FQLS 2

0.035

0.076

0.178

0.312

0.422

0.465

3

WL

0.040

0.103

0.257

0.398

0.519

0.609

FQLS 1

0.039

0.112

0.257

0.404

0.526

0.623

FQLS 2

0.036

0.110

0.253

0.407

0.527

0.621

4

WL

0.041

0.127

0.297

0.497

0.626

0.720

FQLS 1

0.044

0.129

0.307

0.502

0.626

0.719

FQLS 2

0.046

0.126

0.307

0.493

0.637

0.726

0.001

1

WL

0.005

0.012

0.038

0.075

0.113

0.153

FQLS 1

0.005

0.012

0.038

0.076

0.115

0.157

FQLS 2

0.003

0.010

0.038

0.076

0.106

0.163

2

WL

0.006

0.019

0.060

0.098

0.193

0.224

FQLS 1

0.007

0.018

0.059

0.099

0.199

0.217

FQLS 2

0.006

0.019

0.064

0.100

0.197

0.219

3

WL

0.004

0.018

0.086

0.164

0.267

0.337

FQLS 1

0.007

0.020

0.091

0.162

0.275

0.333

FQLS 2

0.008

0.023

0.087

0.165

0.275

0.348

4

WL

0.010

0.029

0.116

0.231

0.309

0.451

FQLS 1

0.009

0.029

0.116

0.228

0.370

0.449

FQLS 2

0.009

0.031

0.118

0.233

0.363

0.459

  1. The bold text indicates the highest empirical estimate of the power for each situation