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Table 1 Empirical type-1 error estimates. The empirical type-1 error rates and their 95 % confidence intervals were estimated with 5000 replicates at the 0.01 and 0.05 significance level for h2 = 0.2, 0.5, and 0.8. The number of families was assumed to be 900, and the disease allele frequency was 0.2

From: Adjusting heterogeneous ascertainment bias for genetic association analysis with extended families

 

h 2

Statistics

Type-1 error estimates

95 % confidence interval

Lower

Upper

0.01

0.2

FQLS 1

0.011

0.008

0.014

FQLS 2

0.011

0.008

0.013

0.5

FQLS 1

0.010

0.007

0.013

FQLS 2

0.009

0.007

0.012

0.8

FQLS 1

0.009

0.006

0.011

FQLS 2

0.009

0.007

0.012

0.05

0.2

FQLS 1

0.049

0.043

0.055

FQLS 2

0.049

0.043

0.055

0.5

FQLS 1

0.050

0.044

0.056

FQLS 2

0.053

0.047

0.059

0.8

FQLS 1

0.047

0.042

0.053

FQLS 2

0.053

0.047

0.059