Independent and combined effects of environmental factors and CYP2C19 polymorphisms on the risk of esophageal squamous cell carcinoma in Fujian Province of China

Table 3 SNPs identified for CYP2C19

Nomenclature	SNP	Nucleotide changes	Effect	MAF ^a				P value for HWF in Controls
Nomenclature	SNP	Nucleotide changes	Effect	NCBI ^b	Controls	Cases	P value for association analysis ^c	P value for HWF in Controls
CYP2C19*2 (exon5)	rs4244285	G681A	Splicing defect	0.256	0.335	0.488	2.31 × 10^-5	0.09
CYP2C19*3 (exon4)	rs4986893	G636A	W212X	0.058	0.054	0.040	0.053	0.177

HWE: Hardy–Weinberg equilibrium; MAF: minor allele frequency.
^aMajor/minor allele.
^bMAF for Chinese in the NCBI dbSNPs database. (http://0-www-ncbi-nlm-nih-gov.brum.beds.ac.uk/SNP).
^cAfter correcting for multiple testing by Haploview software using 1000 permutations.

ISSN: 1471-2350