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Table 3 Univariate analysis for polymorphisms rs11615 ( ERCC1 ) and rs17503908 ( ATM ) and clinical variables

From: Single nucleotide polymorphisms in DNA repair genes as risk factors associated to prostate cancer progression

    Recessive model Dominant model Homozygote Heterozygote
    GG vs. AG + AA GG + AG vs. AA GG vs. AA AG vs. AA
Clinical variable n SNP OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P
cT, 1a-2a/2b-4 270/207 rs11615 1.02 (0.62 – 1.68) 0.928 0.50 (0.35 – 0.73) <0.0001 0.67 (0.39 – 1.16) 0.152 0.45 (0.30 – 0.70) <0.0001
    GG vs. GT + TT GG + GT vs. TT GG vs. TT GT vs. TT
    OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P
Gleason, <7/ ≥ 7 226/266 rs17503908 NA 0.48 (0.30 – 0.76) 0.002 NA 0.45 (0.28 – 0.72) 0.001
  1. Abbreviations: OR odds ratio, CI confidence interval, NA not applicable (due to the limited sample size: only 2 subjects genotyped as GG-rs17503908).
  2. Statistical test: binary logistic regression (Reference category for SNP rs11615: AA. Reference category for SNP rs17503908: TT).