The impact of coronary artery disease risk loci on ischemic heart failure severity and prognosis: association analysis in the COntrolled ROsuvastatin multiNAtional trial in heart failure (CORONA)

Table 2 CAD loci ( P < 0.05) and heart failure disease markers in genetic sub-study of CORONA

	Locus	SNP	Model	n	Beta estimate	95% CI	P value	Excluded from adjusted analysis
LVEF	9p21.3	rs1333049	Unadj.	3,300	0.0044	0.0015 - 0.0074	3.6 × 10⁻³	LVEF
			Adj.^a	2,212	0.0038	0.0005 - 0.0071	2.3 × 10⁻²
	10q11.21	rs501120	Unadj.	3,300	0.0054	0.0012 - 0.0097	1.2 × 10⁻²
			Adj.^a	2,216	0.0022	−0.0025 - 0.0068	0.36
	15q22.33	rs17228212	Unadj.	3,303	−0.005	−0.0084 - -0.0016	4.0 × 10⁻³
			Adj.^a	2,218	−0.0031	−0.0069 - 0.0008	0.12
log NT-proBNP (pmol/L)	10q11.21	rs501120	Unadj.	2,412	−0.11	−0.20 - -0.01	2.7 × 10⁻²	log NT-proBNP (pmol/L)
			Adj.^a	2,216	−0.064	−0.14 - 0.02	0.12
BMI (kg/m2)	1q41	rs17465637	Unadj.	3,298	0.35	0.11 - 0.60	4.8 × 10⁻³	BMI (kg/m2)
			Adj.^a	2,220	0.3	0.03 - 0.58	2.9 × 10⁻²
Serum creatinine (umol/L)	10q11.21	rs501120	Unadj.	3,300	−2.01	−3.80 - -0.21	2.8 × 10⁻²	Serum creatinine (umol/L)
			Adj.^a	2,216	−0.43	−2.25 - 1.39	0.65

Abbreviations: SNP single nucleotide polymorphism, LVEF left ventricular ejection fraction, BMI body mass index, NT-proBNP N-terminal pro B-type natriuretic peptide. ^aAdjusted analyses were adjusted for age, sex, ejection fraction, NYHA class, systolic blood pressure, heart rate, body mass index, history of myocardial infarction, angina pectoris, diabetes mellitus, hypertension, stroke, intermittent claudication, aortic aneurysm, percutaneous coronary intervention, coronary artery bypass graft surgery, atrial fibrillation, implanted pacemaker, implanted cardiac defibrillator, smoking status, serum creatinine, alanine aminotransferase, creatine kinase, thyroid-stimulating hormone, triglycerides, hsCRP and NT-proBNP [10]. As some covariates were also baseline variables or strongly associated to a baseline variable, covariates were excluded from analyses (see Additional file 3: Table S2). Results of all regression analyses for all SNPs are in Additional file 4: Table S3.

ISSN: 1471-2350