Table 6 Individual SNP associations with AAO of PD
From: Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson’s disease – a multicenter study
Sweden PD-Goth | Italy | Sweden PD-Link | Malta | Poland | Germany | Meta-analysis 2 | |||
|---|---|---|---|---|---|---|---|---|---|
SNP 1 | Genotype | Years/allele (CI) | Years/allele (CI) | Years/allele (CI) | Years/allele (CI) | Years/allele (CI) | Years/allele (CI) | Years/allele (CI) | p-value |
2 – rs7557529 | G > A | −1.7 (−3.9 – +0.6) | −0.4 (−2.0 – +1.3) | −2.2 (−4.3 – -0.1) | −0.8 (−4.7 – +3.1) | −0.2 (−2.4 – +2.0) | −0.8 (−6.0 – +4.3) | −0.99 (−1.94 – -0.03) | 0.042 |
P1 – rs35652124 | A > G | −2.1 (−4.5 – +0.3) | −1.3 (−3.3 – +0.7) | −1.8 (−4.1 – +0.5) | −1.6 (−5.8 – +2.6) | +0.2 (−2.0 – +2.4) | +2.8 (−2.3 – +7.8) | −1.07 (−2.12 – -0.02) | 0.045 |
P2 – rs6706649 | G > A | +1.4 (−1.8 – +4.7) | +1.4 (−0.9 – +3.8) | +1.4 (−1.5 – +4.2) | −0.0 (−5.2 – +5.2) | −0.6 (−3.7 – +2.5) | −1.7 (−9.5 – +6.0) | +0.85 (−0.49 – +2.19) | 0.22 |
P3 – rs6721961 | C > A | −1.5 (−5.0 – +2.0) | −0.7 (−2.7 – +1.3) | +2.1 (−1.4 – +5.6) | +2.7 (−3.2 – +8.6) | +0.3 (−2.8 – +3.3) | +0.0 (−6.0 – +6.1) | −0.81 (−2.03 – +0.41) | 0.19 |
3 – rs2886161 | A > G | −2.4 (−4.8 – -0.1) | −1.4 (−3.4 – +0.6) | −2.0 (−4.3 – +0.3) | −1.5 (−5.6 – +2.7) | +0.0 (−2.2 – +2.2) | +2.7 (−2. 4 – +7.8) | −1.23 (−2.27 – -0.18) | 0.021 |
4 – rs1806649 | G > A | +2.7 (+0.2 – +5.1) | +0.4 (−1.5 – +2.4) | +2.7 (+0.4 – +4.9) | −2.4 (−7.0 – +2.1) | +1.0 (−1.7 – +3.7) | −3.6 (−9.5 – +2.3) | +1.20 (+0.12 – +2.28) | 0.029 |
5 – rs2001350 | A > G | −0.6 (−4.3 – +3.0) | −0.8 (−3.1 – +1.6) | +1.8 (−1.9 – +5.6) | +1.8 (−5.1 – +8.8) | −0.7 (−4.1 – +2.8) | +1.1 (−5.7 – +7.8) | −0.11 (−1.59 – +1.37) | 0.88 |
6 – 10183914 | G > A | +3.7 (+1.3 – +6.2) | +0.3 (−1.3 – +2.0) | +1.5 (−0.6 – +3.7) | −0.4 (−4.2 – +3.3) | −0.1 (−2.4 – +2.3) | −1.4 (−6.2 – +3.5) | +0.95 (−0.04 – +1.94) | 0.06 |