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Table 3 Replication of haplotype associations with risk of PD

From: Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson’s disease – a multicenter study

  

Sweden PD-Goth

Italy

Sweden PD-Link

Malta

Poland

Germany

Meta-analysis 2

 

SNP 1

Haplotypes

OR/allele (CI)

OR/allele (CI)

OR/allele (CI)

OR/allele (CI)

OR/allele (CI)

OR/allele (CI)

OR/allele (CI)

p-value

2, 3, 4, 5, 6

GAAAA

0.8 (0.5 – 1.1)

1.1 (0.9 – 1.5)

0.9 (0.7 – 1.2)

0.8 (0.6 – 1.3)

0.7 (0.5 – 0.9)

0.7 (0.4 – 1.3)

0.88 (0.76 – 1.03)

0.052

GAGGG

2.1 (1.2 – 3.8)

1.2 (0.8 – 1.7)

0.9 (0.5 – 1.3)

0.7 (0.4 – 1.3)

1.0 (0.6 – 1.6)

1.1 (0.5 – 2.5)

1.00 (0.81 – 1.24)

0.50

GAAAG

2.8 (1.0 – 7.7)

2.8 (1.1 – 6.8)

0.4 (0.1 – 1.2)

0.0 (0.0 – 2.9 × 1018)

0.5 (0.2 – 1.7)

0.0 (0.0 – 21.6)

0.98 (0.54 – 1.77)

0.53

P1, P2, P3

AGC

1.0 (0.7 – 1.3)

1.1 (0.9 – 1.3)

0.8 (0.6 – 1.1)

1.0 (0.7 – 1.3)

0.8 (0.6 – 1.0)

0.9 (0.5 – 1.5)

0.92 (0.81 – 1.04)

0.09

2, P1, P2, P3, 3, 4, 5, 6

GAGCAAAA

0.8 (0.6 – 1.1)

1.1 (0.9 – 1.5)

0.9 (0.7 – 1.2)

0.8 (0.6 – 1.3)

0.5 (0.3 – 0.7)

0.7 (0.4 – 1.3)

0.84 (0.72 – 0.98)

0.012

GAGAAGGG

2.4 (1.3 – 4.5)

1.2 (0.9 – 1.8)

0.9 (0.6 – 1.4)

0.8 (0.4 – 1.4)

0.6 (0.3 – 1.0)

1.1 (0.5 – 2.5)

0.95 (0.76 – 1.18)

0.68

GAGCAAAG

2.9 (1.0 – 8.4)

2.8 (1.1 – 6.8)

0.4 (0.1 – 1.2)

0.0 (0.0 – 3.3 × 1036)

0.4 (0.1 – 1.5)

0.0 (0.0 – 29.2)

0.95 (0.52 – 1.72)

0.57

  1. Odds ratios (OR) are presented as absolute numbers (95% CI). Sex was used as covariate for all materials except for Poland, where the number of males and females are identical in patients and controls. Statistically significant p-values are highlighted in bold.
  2. 1For SNP locations see Figure 1 and Table 2.
  3. 2The meta-analysis was calculated using inverse-variance weighting of effects with one-sided p-values and included all materials except Sweden PD-Goth, since it is the discovery material on which the haplotype selection was based.