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Table 4 Relative risk A of lymphoma-specific death and lymphoma progression for selected SNPs previously associated with any follicular lymphoma outcome in at least one previous study

From: A comprehensive evaluation of the role of genetic variation in follicular lymphoma survival

        Lymphoma-specific death ProgressionB  
Chr Gene SNP Position A1 A2 MAF HR (95% CI)A p-value HR (95% CI)A p-value
1 CD46 rs2466571 206006669 A C 0.49 0.98 (0.73; 1.32) 0.90 1.37 (1.10; 1.72) 0.006
1 CD55 rs2564978C 205561039 T C 0.31 0.88 (0.62; 1.25) 0.47 1.13 (0.86; 1.49) 0.38
1 CFH rs1065489 194976397 A C 0.15 0.89 (0.57; 1.39) 0.60 0.92 (0.65; 1.31) 0.66
1 CFH rs1329423C 194913010 C T 0.22 0.94 (0.66; 1.39) 0.81 1.06 (0.79; 1.42) 0.71
1 CFH rs3766404 194918455 G A 0.16 1.14 (0.77; 1.68) 0.51 1.12 (0.80; 1.55) 0.52
1 CFHR5 rs6694672C 195212412 G T 0.09 1.01 (0.61; 1.67) 0.97 1.02 (0.66; 1.57) 0.93
1 FCGR2A rs1801274 159746369 A G 0.47 0.76 (0.56; 1.03) 0.08 0.86 (0.68; 1.08) 0.19
1 MTHFR rs1801131C 11777063 G T 0.32 0.69 (0.49; 0.97) 0.03 0.59 (0.45; 0.77) 0.0001E
1 SELE rs5361 167967684 C A 0.11 1.04 (0.64; 1.69) 0.89 0.90 (0.61; 1.32) 0.59
2 IL1RN rs454078C 113605264 T A 0.28 0.99 (0.69; 1.42) 0.96 0.94 (0.72; 1.23) 0.66
3 FTHFD rs1127717C 127308749 C T 0.16 0.91 (0.58; 1.43) 0.69 0.98 (0.70; 1.38) 0.92
4 IL2 rs2069762C 123597430 C A 0.26 0.63 (0.43; 0.92) 0.02 0.89 (0.69; 1.16) 0.38
4 IL8 rs4073C 74824888 A T 0.46 0.93 (0.70; 1.25) 0.64 0.78 (0.62; 0.97) 0.02
4 IL8 rs2227307C 74825533 G T 0.45 0.93 (0.69; 1.25) 0.63 0.75 (0.60; 0.94) 0.01
5 C9 rs1421094C 39391348 A G 0.37 1.19 (0.88; 1.61) 0.27 1.00 (0.79; 1.27) 0.98
5 IL12B rs3212227C 158675528 G T 0.17 1.21 (0.81; 1.80) 0.36 1.42 (1.03; 1.94) 0.03
6 C6orf15 rs6457327D 31182009 A C 0.42 0.90 (0.66; 1.24) 0.53 0.90 (0.71; 1.14) 0.38
6 IFNGR1 rs3799488 137561473 G A 0.12 0.76 (0.46; 1.24) 0.27 1.12 (0.79; 1.57) 0.53
8 GGH rs719235C 64114235 A C 0.32 0.96 (0.69; 1.34) 0.82 1.00 (0.77; 1.29) 0.99
9 GALNT12 rs10819377 100643533 A G 0.46 0.76 (0.56; 1.03) 0.07 0.89 (0.71; 1.12) 0.33
16 IL4R rs1801275 27281901 G A 0.25 0.91 (0.64; 1.30) 0.62 0.85 (0.65; 1.12) 0.26
22 MIF rs755622C 22566392 C G 0.16 0.76 (0.49; 1.16) 0.20 0.85 (0.61; 1.18) 0.34
  1. AEstimated with Hazard ratio, HR, and 95% confidence interval, CI. Adjusted for age at diagnosis, sex and three principal components.
  2. BSwedish cases only (n = 231) for time to progression.
  3. CImputed SNP.
  4. Drs6457327 has previously been associated with both FL risk and prognosis.
  5. EOpposite direction of association to previous study [15].
  6. The minor allele (A1) was investigated for association except for rs2466571 (CD46), where the major allele (A2) was used as reference for easier comparison with previous study result.