From: A comprehensive evaluation of the role of genetic variation in follicular lymphoma survival
Chr | Gene | SNP | Minor/major allele | Study | # FL cases | # SNPs tested | Outcome | Relative risk ratio | # Studies reporting no association [refs] |
---|---|---|---|---|---|---|---|---|---|
1 | C1qA | rs172378 | A/G | Racilia 2008 | 133 | 3 | PFS | 2.5 (2.0, 3.1) | none |
1 | CD46 | rs2466571 | C/A | Charbonneau 2012 | 107 | 167 | EFS | 1.49 (0.86, 2.61), ptrend < 0.05 | none |
1 | CD55 | rs2564978 | T/C | Charbonneau 2012 | 107 | 167 | EFS | 0.52 (0.30, 0.88) | none |
1 | CFH | rs1065489 | T/G | Charbonneau 2012 | 107 | 167 | EFS | 0.44 (0.24, 0.81) | none |
1 | CFH | rs1329423 | C/T | Charbonneau 2012 | 107 | 167 | EFS | 0.49 (0.29, 0.82) | none |
1 | CFH | rs3766404 | G/A | Charbonneau 2012 | 107 | 167 | EFS | 2.25 (1.31, 3.87) | none |
1 | CFHR1 | rs436719A | C/A | Charbonneau 2012 | 107 | 167 | EFS | 0.57 (0.34, 0.96) | none |
1 | CFHR5 | rs6694672 | G/T | Charbonneau 2012 | 107 | 167 | EFS | 2.63 (1.41, 4.92) | none |
1 | FCGR2A | rs1801274 | A/G | Weng 2003 | 87 | 2 | PFS | Decreased rate, plog-rank < 0.02 | |
 |  |  | A/G | Cerhan 2007 | 278 | 73 | OS | 0.58 (0.31, 1.04), ptrend = 0.04 | |
1 | FCGR3A | rs396991A | G/T | Weng 2003 | 87 | 2 | PFS | Decreased rate, plog-rank < 0.03 | |
 |  |  | G/T | Ghielmini 2005 | 185 | 1 | EFS | 0.5 (0.3, 0.9) | 1 [5] |
 |  |  | G/T | Persky 2012 | 142 | 2 | OS | 0.33 (0.11; 0.96) | 1 [10] |
 |  |  | G/T | Cartron 2002 | 49 | 2 | RR | 1.5 (1.2, 1.9) | 1 [10] |
1 | MTHFR | rs1801131 | C/A | Wang 2009 | 192 | 66 | OS | 2.00 (1.04, 3.84) | none |
1 | SELE | rs5361 | Â | Aschenbrook- Kilfoy 2012 | 117 | 82 | OS | 0.10 (0.02, 0.48) | 1 [7] |
2 | IL1RN | rs454078 | T/A | Cerhan 2007 | 278 | 73 | OS | 0.50 (0.28, 0.87) | 1 [3] |
3 | CCR2 | rs1799864A | Â | Aschenbrook- Kilfoy 2012 | 117 | 82 | OS | 0.27 (0.08, 0.86) | 1 [7] |
3 | FTHFD | rs1127717 | G/A | Wang 2009 | 192 | 66 | OS | 1.99 (1.07, 3.7) | none |
4 | IL2 | rs2069762 | G/T | Cerhan 2007 | 278 | 73 | OS | 1.81 (1.06, 3.07) | none |
4 | IL8 | rs4073 | T/A | Aschenbrook- Kilfoy 2012 | 117 | 82 | OS | 2.60 (1.10, 6.15) | none |
 |  |  | A/T | Cerhan 2007 | 278 | 73 | OS | 0.47 (0.27, 0.79), ptrend = 0.06 | none |
4 | IL8 | rs2227307 | T/G | Aschenbrook- Kilfoy 2012 | 117 | 82 | OS | 2.57 (1.07, 6.17) | none |
 |  |  | G/T | Cerhan 2007 | 278 | 73 | OS | 0.53 (0.31, 0.91), ptrend = 0.11 | none |
4 | IRF2 | rs3775567A | T/ | Gibson 2012A | 244 | 6679 | OS | 3.18 (1.72, 5.87) | none |
5 | C9 | rs1421094 | A/G | Charbonneau 2012 | 107 | 167 | EFS | 0.54 (0.32, 0.90) | none |
5 | IL12B | rs3212227 | C/A | Cerhan 2007 | 278 | 73 | OS | 2.01 (1.18, 3.42) | none |
6 | C6orf15 | rs6457327 | A/C | Wrench 2011 | 218 | 2 | TTT | 2.25. (1.16, 4.36) | none |
 |  |  |  | Berglund 2011 | 102 | 1 | OS | Increased rate, p = 0.006 | none |
6 | IFNGR1 | rs3799488 | Â | Aschenbrook- Kilfoy 2012 | 117 | 82 | OS | 3.19 (1.09, 9.34) | 1 [7] |
8 | GGH | rs719235 | T/G | Wang 2009 | 192 | 66 | OS | 2.49 (1.21, 5.14) | none |
9 | GALNT12 | rs10987898A | G/ | Gibson 2012A | 244 | 6679 | OS | 0.48 (0.27, 0.83) | none |
9 | GALNT12 | rs10819377 | T/ | Gibson 2012A | 244 | 6679 | OS | 0.62 (0.36, 1.03), ptrend < 0.001 | none |
11 | CXCR5 | rs1790192 | G/A | Charbonneau 2013A | 172 | 10 | EFS | 0.64 (0.47; 0.87) | none |
16 | IL4R | rs1801275 | Â | Aschenbrook- Kilfoy 2012 | 117 | 82 | OS | 2.35 (1.07, 5.19) | none |
20 | BMP7 | rs6025446A | G/A | Gibson 2012A | 244 | 6679 | OS | 0.41 (0.21, 0.69) | none |
22 | MIF | rs755622 | Â | Aschenbrook- Kilfoy 2012 | 117 | 82 | OS | 2.45 (1.09,5.47) | none |