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Table 3 Linear model results on the 11 selected single nucleotide polymorphisms using an additive genetic model

From: Genetic polymorphisms at SIRT1 and FOXO1 are associated with carotid atherosclerosis in the SAPHIR cohort

 

Mean common carotid IMT (n = 1689)

Mean internal carotid IMT (n = 1687)

Mean B-score (n = 1759)

SNP

Age-and sex-adjusted

Fully adjusted

Age-and sex-adjusted

Fully adjusted

Age-and sex-adjusted

Fully adjusted

 

β (se)

p-value

β (se)

p-value

β (se)

p-value

β (se)

p-value

β (se)

p-value

β (se)

p-value

FOXO1

            

rs17446593

-0.00046 (0.00052)

0.3934

-0.00047 (0.00052)

0.3821

0.00041 (0.00057)

0.5654

0.00053 (0.00056)

0.4289

0.00391 (0.02081)

0.7763

0.00648 (0.02066)

0.6889

rs2721068

-0.00089 (0.00045)

0.0412

-0.00106 (0.00045)

0.0145

-0.00049 (0.00049)

0.2739

-0.00055 (0.00048)

0.2224

-0.01029 (0.01803)

0.6473

-0.01329 (0.01786)

0.5229

rs17446614

-0.00118 (0.00054)

0.0272

-0.00125 (0.00053)

0.0180

-0.00032 (0.00058)

0.4625

-0.00027 (0.00058)

0.5278

-0.00860 (0.02131)

0.7509

-0.00725 (0.02118)

0.7789

rs10507486

-0.00168 (0.00042)

0.0007

-0.00184 (0.00047)

0.0002

-0.00083 (0.00052)

0.1080

-0.00079 (0.00052)

0.1278

-0.02940 (0.01907)

0.1178

-0.03007 (0.01898)

0.1007

rs2297627

-0.00144 (0.00042)

0.0008

-0.00158 (0.00042)

0.0002

-0.00100 (0.00046)

0.0333

-0.00104 (0.00045)

0.0253

-0.03310 (0.01681)

0.0516

-0.03620 (0.01664)

0.0301

SIRT1

            

rs3740051

0.00048 (0.00082)

0.5530

0.00053 (0.00081)

0.5012

0.00044 (0.00088)

0.7644

0.00068 (0.00088)

0.5590

0.00096 (0.03260)

0.9972

0.00816 (0.03250)

0.8322

rs2236319

0.00033 (0.00082)

0.7001

0.00039 (0.00081)

0.6382

0.00016 (0.00088)

0.9579

0.00039 (0.00088)

0.7410

-0.00578 (0.03272)

0.8706

0.00484 (0.03254)

0.8668

rs12413112

0.00177 (0.00061)

0.0157

0.00206 (0.00061)

0.0037

0.00100 (0.00066)

0.1375

0.00108 (0.00066)

0.1064

0.05019 (0.02423)

0.0847

0.04818 (0.02411)

0.0989

rs10823108

0.00031 (0.00081)

0.6926

0.00038 (0.00080)

0.6102

-0.00002 (0.00087)

0.9096

0.00024 (0.00087)

0.8477

-0.01326 (0.03240)

0.6779

-0.00217 (0.03222)

0.9476

rs2273773

0.00052 (0.00081)

0.5360

0.00059 (0.00081)

0.4716

0.00023 (0.00088)

0.9143

0.00045 (0.00088)

0.7025

-0.00549 (0.03257)

0.8698

0.00502 (0.03239)

0.8692

rs1467568

0.00034 (0.00042)

0.5594

0.00045 (0.00041)

0.3747

0.00063 (0.00045)

0.2329

0.00072 (0.00045)

0.1563

0.03433 (0.01659)

0.0775

0.03577 (0.01645)

0.0643

  1. β-estimate and se: based on original scale of phenotype variables; p-value: based on log-transformed phenotype variables.
  2. Full-adjusted model: age, sex, BMI, total cholesterol, HDL-cholesterol, current smoking status, hypertension, hsCRP.
  3. In bold: Significant p-values after correction for multiple testing.