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Table 1 case–control replication analyses in the New York State NTD cohort

From: Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects

Gene SNP

Test/Model*

Result in Irish NTD Cohort [[45]]

Result in NYS NTD Cohort

GRR [95% CI], p-value

GRR [95% CI], p-value

ADA rs6031682

LR CC Dom

0.67 [0.52-0.86], p = 0.0016

0.92 [0.63-1.33], p = 0.653

ALDH1A2 rs7169289

LR CC Dom

0.71 [0.56-0.90], p = 0.0043

1.07 [0.77-1.47], p = 0.697

ARID1A rs11247593

LR CC Cont

1.35 [1.11-1.64], p = 0.0027

0.81 [0.63-1.04], p = 0.092

CDKN2A rs7041637

LR CC Cont

0.69 [0.53-0.89], p = 0.0048

1.07 [0.85-1.36], p = 0.564

CTH rs12733999

LR CC Rec

0.57 [0.39-0.84], p = 0.0048

1.12 [0.65-1.92], p = 0.692

ENOSF1 rs1059384

LR CC Rec

1.84 [1.23-2.75], p = 0.0028

0.98 [0.60-1.60], p = 0.937

FOLH1 rs383028

LR CC Cont

0.58 [0.39-0.85], p = 0.0051

1.07 [0.76-1.52], p = 0.697

MFTC rs17803441

LR CC Cont

0.62 [0.48-0.81], p = 0.0003

1.02 [0.66-1.58], p = 0.922

MTHFD1L rs2295083

LR CC Rec

0.60 [0.43-0.85], p = 0.0038

1.25 [0.89-1.76], p = 0.193

  1. *LR CC = logistic regression, case–control; genetic models: Dom (dominant), Cont (continuous) and Rec (recessive).