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Figure 3 | BMC Medical Genetics

Figure 3

From: Genetic determinants of glucose-6-phosphate dehydrogenase activity in Kenya

Figure 3

Haplotype-based association testing for effects independent of c.202G>A. Results of association testing of a, full-length and b, partial/twelve-site haplotypes are shown for all haplotype tests suggestive of association (P<0.025, covariates: gender, c.202G>A genotype), with haplotypes defined by patterns of ancestral (blue) and derived (yellow) alleles. SNP labels for the twelve sites that comprise the partial haplotypes are colored according to whether they exhibited positive ES [green] or negative ES (red) in single SNP controlled tests (Figure 2). c, G6PD activity distribution in c.202G>A wild-type homozygotes (202G or 202GG) as stratified by carriage of H+, H-, or neither haplotype. Pairwise t-test results are shown via asterisk (*: P<0.05 and ***: P=9.1 × 10-5). In box-and-whisker plot, center of box represents median, edges of box represent upper and lower quartile bounds, and whiskers represent either minimum and maximum values or 1.5 times the interquartile range, whichever is less extreme.

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