Table 2 Association of TCF7L2 variants with type 2 diabetes mellitus among UK-resident South Asians
SNP | Allele | Diabetic subjects Fa | Control subjects Fa | Genotype | Diabetic subjects n (%)b | Control subjects n (%)b | Allelic ORc (95% CI) | Het ORc,d (95% CI) | Hom ORc,d (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
T | 0.65 | 0.71 | TT | 362 (43.7) | 226 (51.7) | 1.29 (1.09 – 1.54) | 1.31 (1.02 – 1.68) | 1.65 (1.12 – 2.44) | |
rs7901695 | CT | 355 (42.9) | 169 (38.7) | ||||||
C | 0.35 | 0.29 | CC | 111 (13.4) | 42 (9.6) | p = 3.60 × 10-3 | p = 0.032 | p = 0.012 | |
C | 0.64 | 0.71 | CC | 352 (42.5) | 222 (51.4) | 1.31 (1.11 – 1.56) | 1.37 (1.07 – 1.76) | 1.66 (1.13 – 2.44) | |
rs7903146 | CT | 360 (43.5) | 166 (38.4) | ||||||
T | 0.36 | 0.29 | TT | 116 (14.0) | 44 (10.2) | p = 1.96 × 10-3 | p = 0.014 | p = 9.74 × 10-3 | |
G | 0.53 | 0.59 | GG | 229 (27.5) | 159 (36.5) | 1.30 (1.11 – 1.54) | 1.46 (1.12 – 1.89) | 1.65 (1.18 – 2.30) | |
rs11196205 | CG | 417 (50.2) | 199 (45.6) | ||||||
C | 0.47 | 0.41 | CC | 185 (22.3) | 78 (17.9) | p = 1.10 × 10-3 | p = 5.29 × 10-3 | p = 3.33 × 10-3 | |
G | 0.68 | 0.73 | GG | 382 (46.8) | 241 (55.4) | 1.26 (1.05 – 1.51) | 1.43 (1.11 – 1.83) | 1.37 (0.92 – 2.05) | |
rs12255372 | GT | 346 (42.3) | 153 (35.2) | ||||||
T | 0.32 | 0.27 | TT | 89 (10.9) | 41 (9.4) | p = 3.60 × 10-3 | p = 5.23 × 10-3 | p = 0.127 |