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Table 1 HLA-DRB1 distribution in Mexican Mestizo patients with narcolepsy and in healthy controls.

From: Association of narcolepsy-cataplexy with HLA-DRB1 and DQB1in Mexican patients: A relationship between HLA and gender is suggested

Locus

Total Patients

Total Controls

     

DRB1*

N = 27†

AF%

N = 203

AF%

X2Y

OR

(CI)

p

pc

0101

0

0

11

2.7

0.6

    

0102

0

0

17

4.2

1.3

    

0103

0

0

2

0.5

0.3

    

1001

1

1.8

3

0.7

0

    

1101

3

5.6

12

3

0.4

    

1102

0

0

4

1

0

    

1103

0

0

1

0.2

1.4

    

1104

2

3.7

9

2.2

0

    

1201

0

0

4

1

0

    

1301

0

0

9

2.2

0.3

    

1302

1

1.8

10

2.5

0

    

1303

2

3.7

4

1

1

    

1304

1

1.8

1

0.2

0.3

    

1305

0

0

1

0.2

1.4

    

1401

0

0

5

1.2

0

    

1402

2

3.7

14

3.4

0.1

    

1406

0

0

24

5.9

2.3

    

1501

15

27.8

18

4.4

35.6

8.2

(3.9–17.6)

<0.0001

<0.0001

1502

2

3.7

5

1.2

0.6

    

1503

2

3.7

2

0.5

2.6

    

1504

1

1.8

0

0

1.4

    

1601

0

0

4

1

0

    

1602

1

1.8

21

5.2

0.5

    

0301

3

5.6

18

4.4

0

    

0302

0

0

3

0.7

0.1

    

0401

0

0

1

0.2

1.4

    

0402

0

0

7

1.7

0.1

    

0403

3

5.6

7

1.7

1.7

    

0404

3

5.6

17

4.2

0

    

0405

0

0

12

3

0.7

    

0407

1

1.8

60

14.8

5.8

0.2

(0.02–1.2)

0.016

NS

0410

0

0

2

0.5

0.3

    

0411

2

3.7

12

3

0

    

0701

4

7.4

27

6.7

0

    

0801

0

0

6

1.5

0.1

    

0802

3

5.6

51

12.6

1.6

    

0804

1

1.8

0

0

1.4

    

0806

1

1.8

0

0

1.4

    

0901

0

0

2

0.5

0.3

    
  1. AF: allele frequency; X2Y: Chi2 value with Yates correction; OR: Odds Ratio; CI: Confidence Interval; pc: Bonferroni correction (the p value was multiplied by the total number of alleles tested); NS: Not significant; †5/32 patients were not typed for DRB1 locus.
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BMC Medical Genetics

ISSN: 1471-2350

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