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Table 3 Up/down regulated genes in PBMC lacking ARHGAP4

From: Immunological profile in a family with nephrogenic diabetes insipidus with a novel 11 kb deletion in AVPR2 and ARHGAP4 genes

Gene Name

Description

aFold change

b q value

cAccession

Up-regulation

PLK3

Polo-like kinase 3

4.35

0.0402

NM_004073

NHSL2

NHS-like 2

2.38

0.0453

NM_001013627

PTAFR

Platelet-activating factor receptor

2.27

0.0288

NM_000952

KLHL26

Kelch-like 26

1.99

0.0272

NM_018316

MAPKAPK2

Mitogen-activated protein kinase- activated protein kinase 2

1.96

0.0442

NM_032960

CKAP4

Cytoskeleton-associated protein 4

1.85

0.0272

NM_006825

CYB5R3

Cytochrome b5 reductase 3

1.82

0.0328

NM_007326

ZC3H12A

Zinc finger CCCH-type containing

1.81

0.0428

NM_025079

FURIN

Furin

1.79

0.0448

NM_002569

GRN

Granulin

1.76

0.0453

NM 002087

PPOX

Protoporphyrinogen oxidase

1.75

0.0307

NM_000309

NQO2

NAD(P)H dehydrogenase, quinone 2

1.74

0.0453

NM_000904

DPH3

Diphthamide biosynthesis protein 3

1.70

0.0307

NM_206831

PGD

Phosphogluconate dehydrogenase

1.68

0.00562

NM_002631

RIPK5

Receptor interacting protein kinase 5

1.66

0.0386

NM_015375

CD14

CD14 molecule

1.62

0.0272

NM_000591

PGD

Phosphogluconate dehydrogenase

1.57

0.0272

NM_002631

Down-regulation

    

TUSC4

Tumor suppressor candidate 4

0.63

0.0453

NM_006545

PLEKHG4

Pleckstrin homology domain containing, family G (with RhoGef

0.62

0.0272

NM_015432

SFXN1

Sideroflexin 1

0.61

0.0272

NM_022754

GNRH1

Gonadotropin-releasing hormone 1

0.60

0.0328

NM_000825

PPP1R3E

Protein phosphatase 1, regulatory

0.60

0.0383

XM_940069

MC1R

Melanocortin 1 receptor

0.56

0.0272

NM_002386

LRCH4

Leucine-rich repeats and calponin homology (CH) domain containing 4

0.55

0.0411

NM_002319

LOC642787

Hypothetical protein LOC642787

0.44

0.0288

XM_926202

SGPP2

Sphingosine-1-phosphate phosphotase

0.09

0.0307

XM_938742

BNIPL

BCL2/adenovirus E1B 19 kD

0.06

0.0226

NM_138278

ARHGAP4

Rho GTPase activating protein 4

0.00

0.000567

NM_001666

  1. aThe fold change was determined by calculating the ratio of global normalized signals from the PBMCs of NDI patients to those from the PBMCs of normal subjects. bP values corrected by the Benjamini and Hochberg false discovery rate, and expressed as q values cGenBank accession numbers