Figure 1

Chromosome 1 peak-wide mapping of genes involved in myocardial infarction. 457 SNPs were genotyped across the 1 LOD down region of linkage on chromosome 1 in the GENECARD ACS sample. Association was assessed using APL. The -log₁₀ of the p-value is plotted according to chromosome position (closed circles). Markers with a p-value less than 0.05 fall above the dashed line; labels identify these genes and intergenic SNPs. Markers in bold exhibited modest evidence for linkage (LOD ≥ 1) in two point analysis. Sixteen markers that were associated (p ≤ 0.05) in the GENECARD ACS sample were genotyped in a MI case-control population (open circles). Markers which show replication are underlined.