PKLRrs3020781 | NOS1APrs7538490 | |||||||
---|---|---|---|---|---|---|---|---|
TT | TC | CC | p Add | CC | CT | TT | p Dom | |
n (men/women) | 3,065 (1,544/1,521) | 2,169 (1,062/1,107) | 356 (180/176) | 2,954 (1,474/1,480) | 2,238 (1,109/1,129) | 438 (221/217) | ||
Age (years) | 46 ± 8 | 46 ± 8 | 45 ± 8 | 46 ± 8 | 46 ± 8 | 46 ± 8 | ||
BMI (kg/m2) | 26.2 ± 4.6 | 26.2 ± 4.5 | 25.9 ± 4.3 | 0.58 | 26.2 ± 4.5 | 26.3 ± 4.6 | 26.1 ± 4.6 | 0.52 |
Plasma glucose (mmol/l) | ||||||||
Fasting | 5.5 ± 0.8 | 5.6 ± 0.9 | 5.5 ± 0.6 | 0.88 | 5.5 ± 0.7 | 5.5 ± 0.8 | 5.6 ± 1.1 | 0.46 |
30-min | 8.7 ± 1.9 | 8.7 ± 1.9 | 8.6 ± 1.9 | 0.31 | 8.7 ± 1.9 | 8.7 ± 1.9 | 8.7 ± 1.8 | 0.90 |
120-min | 6.2 ± 2.2 | 6.2 ± 2.1 | 6 ± 2.0 | 0.33 | 6.2 ± 2.1 | 6.2 ± 2.2 | 6.3 ± 2.1 | 0.22 |
Serum insulin (pmol/l) | ||||||||
Fasting | 34 (23–50) | 35 (24–52) | 31 (24–47) | 0.21 | 34 (24–51) | 34 (23–51) | 34 (24–51) | 0.14 |
30-min | 243 (173–350) | 248 (177–355) | 246 (176–355) | 0.29 | 244 (175–351) | 247 (176–354) | 248 (173–360) | 0.67 |
120-min | 154 (93–253) | 161 (99–258) | 150 (91–234) | 0.45 | 155 (95–251) | 157 (97–257) | 158 (103–256) | 0.59 |
Derived indices | ||||||||
BIGTT-Si | 9.2 (6.4–12.1) | 9.1 (6.2–11.9) | 9.8 (7.1–12.4) | 0.54 | 9.2 (6.5–12.1) | 9.2 (6.2–12.1) | 9.6 (6.0–12.1) | 0.37 |
BIGTT-AIR | 1,622 (1,282–2,083) | 1,625 (1,290–2,058) | 1,634 (1,280–2,092) | 0.84 | 1,618 (1,276–2,048) | 1,643 (1,301–2,118) | 1,632 (1,310–2,125) | 0.05 |
HOMA-IR | 8.2 (5.6–12.6) | 8.5 (5.7–13.4) | 7.7 (5.5–11.4) | 0.24 | 8.3 (5.7–12.9) | 8.4 (5.5–13.1) | 8.0 (5.6–12.6) | 0.14 |