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Table 2 Quantitative metabolic characteristics of 5,590 and 5,630 treatment-naïve individuals from the population-based Inter99 cohort, stratified according to the PKLR rs3020781 genotype and the NOS1AP rs7538490 genotype, respectively

From: Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits

 

PKLRrs3020781

NOS1APrs7538490

 

TT

TC

CC

p Add

CC

CT

TT

p Dom

n

(men/women)

3,065

(1,544/1,521)

2,169

(1,062/1,107)

356

(180/176)

 

2,954

(1,474/1,480)

2,238

(1,109/1,129)

438

(221/217)

 

Age (years)

46 ± 8

46 ± 8

45 ± 8

 

46 ± 8

46 ± 8

46 ± 8

 

BMI (kg/m2)

26.2 ± 4.6

26.2 ± 4.5

25.9 ± 4.3

0.58

26.2 ± 4.5

26.3 ± 4.6

26.1 ± 4.6

0.52

Plasma glucose (mmol/l)

Fasting

5.5 ± 0.8

5.6 ± 0.9

5.5 ± 0.6

0.88

5.5 ± 0.7

5.5 ± 0.8

5.6 ± 1.1

0.46

30-min

8.7 ± 1.9

8.7 ± 1.9

8.6 ± 1.9

0.31

8.7 ± 1.9

8.7 ± 1.9

8.7 ± 1.8

0.90

120-min

6.2 ± 2.2

6.2 ± 2.1

6 ± 2.0

0.33

6.2 ± 2.1

6.2 ± 2.2

6.3 ± 2.1

0.22

Serum insulin (pmol/l)

Fasting

34

(23–50)

35

(24–52)

31

(24–47)

0.21

34

(24–51)

34

(23–51)

34

(24–51)

0.14

30-min

243

(173–350)

248

(177–355)

246

(176–355)

0.29

244

(175–351)

247

(176–354)

248

(173–360)

0.67

120-min

154

(93–253)

161

(99–258)

150

(91–234)

0.45

155

(95–251)

157

(97–257)

158

(103–256)

0.59

Derived indices

BIGTT-Si

9.2

(6.4–12.1)

9.1

(6.2–11.9)

9.8

(7.1–12.4)

0.54

9.2

(6.5–12.1)

9.2

(6.2–12.1)

9.6

(6.0–12.1)

0.37

BIGTT-AIR

1,622

(1,282–2,083)

1,625

(1,290–2,058)

1,634

(1,280–2,092)

0.84

1,618

(1,276–2,048)

1,643

(1,301–2,118)

1,632

(1,310–2,125)

0.05

HOMA-IR

8.2

(5.6–12.6)

8.5

(5.7–13.4)

7.7

(5.5–11.4)

0.24

8.3

(5.7–12.9)

8.4

(5.5–13.1)

8.0

(5.6–12.6)

0.14

  1. Data are means ± standard deviation or median (interquartile range). Values of plasma glucose, serum insulin, HOMA-IR and BIGTT-AIR were logarithmically transformed before statistical analysis to obtain normal distribution. All analyses of PKLR rs3020781 were made using an additive model (Add), while analyses of NOS1AP rs7539480 were made using a dominant model. Calculated p-values were adjusted for age and sex for BMI measures, for sex, age and BMI for serum insulin, plasma glucose and HOMA-IR, and for age for the BIGTT-Si and BIGTT-AIR index. HOMA-IR was calculated as fasting plasma glucose (mmol/l) multiplied by fasting serum insulin (pmol/l) divided by 22.5. BIGTT-Si and BIGTT-AIR were calculated as described [26].