Table 6 Threshold to obtain 90% sensitivity and corresponding specificity
From: Selecting a BRCA risk assessment model for use in a familial cancer clinic
Model | Threshold to obtain 90% sensitivity | Specificity at 90% sensitivity | ||||
|---|---|---|---|---|---|---|
| Â | All | Low risk subset | High risk subset | All | Low risk subset | High risk subset |
BRCA status | Â | Â | Â | Â | Â | Â |
BRCAPRO | 1.97 | 0.47 | 4.20 | 0.21 | 0.06 | 0.39 |
Manchester | 7.58 | 7.60 | 7.10 | 0.27 | 0.17 | 0.31 |
Penn II | 10.90 | 10.65 | 11.20 | 0.35 | 0.18 | 0.45 |
Myriad II | 5.80 | 6.20 | 5.75 | 0.36 | 0.27 | 0.40 |
FHAT | 6.00 | 4.10 | 8.83 | 0.26 | 0.26 | 0.38 |
IBIS | 0.26 | - | - | 0.18 | - | - |
BOADICEA | 2.77 | 1.94 | 3.08 | 0.22 | 0.11 | 0.25 |