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Table 4 Area under the receiver operating characteristic (ROC) curve with 95% confidence limits

From: Selecting a BRCA risk assessment model for use in a familial cancer clinic

Model Area under the ROC curve (95% confidence limits)
  All Low risk subset High risk subset
BRCA status    
BRCAPRO 0.76 (0.70 – 0.82) 0.70 (0.57 – 0.81) 0.80 (0.73 – 0.87)
Manchester 0.68 (0.60 – 0.76) 0.57 (0.37 – 0.72) 0.73 (0.63 – 0.81)
Penn II 0.74 (0.67 – 0.80) 0.68 (0.54 – 0.79) 0.77 (0.70 – 0.83)
Myriad II 0.76 (0.71 – 0.82) 0.70 (0.59 – 0.80) 0.80 (0.72 – 0.86)
FHAT 0.74 (0.66 – 0.80) 0.66 (0.55 – 0.76) 0.83 (0.76 – 0.89)
IBIS 0.47 (0.28 – 0.69) - -
BOADICEA 0.74 (0.67 – 0.80) 0.68 (0.56 – 0.79) 0.77 (0.70 – 0.84)
BRCA1 status    
BRCAPRO 0.80 (0.72 – 0.87) 0.8 (0.62 – 0.91) 0.81 (0.71 – 0.88)
Manchester 0.78 (0.69 – 0.86) 0.74 (0.46 – 0.93) 0.79 (0.69 – 0.88)
Penn II 0.79 (0.72 – 0.85) 0.76 (0.61 – 0.86) 0.81 (0.73 – 0.87)
COUCH 0.82 (0.75 – 0.87) 0.82 (0.65 – 0.92) 0.84 (0.75 – 0.89)
IBIS 0.43 (0.28 – 0.56) - -
BOADICEA 0.80 (0.72 – 0.86) 0.79 (0.61 – 0.89) 0.80 (0.71 – 0.87)
BRCA2 status    
BRCAPRO 0.60 (0.50 – 0.68) 0.57 (0.42 – 0.71) 0.62 (0.48 – 0.73)
Manchester 0.60 (0.49 – 0.70) 0.56 (0.34 – 0.74) 0.63 (0.49 – 0.74)
Penn II 0.57 (0.48 – 0.65) 0.54 (0.39 – 0.69) 0.58 (0.46 – 0.69)
IBIS 0.58 (0.29 – 0.84) - -
BOADICEA 0.63 (0.54 – 0.73) 0.59 (0.41 – 0.76) 0.67 (0.55 – 0.77)