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Table 1 Applicability and ease of use of risk assessment models.

From: Selecting a BRCA risk assessment model for use in a familial cancer clinic

  Calculation method Cancers included Inclusiveness Family history required Data entry
BRCAPRO CaGene 4.3 software Male and female breast and ovarian cancer All individuals 1st and 2nd degree relatives Complete pedigree data entered for affected and unaffected
Myriad II CaGene 4.3 software Male and female breast and ovarian cancer All individuals 1st and 2nd degree relatives Data searchable by established tables or data entry on CaGene 4.3 software
Couch CaGene 4.3 software Male and female breast and ovarian cancer Excludes probands from families with only ovarian or male breast cancer 1st and 2nd degree relatives Data searchable by established table or data entry on CaGene 4.3 software
Ontario Family History Assessment Tool (FHAT) CaGene 4.3 software Male and female breast, ovarian, colon (<50 yrs), prostate cancer (<50 yrs) All individuals 1st and 2nd degree relatives Data searchable by established table or data entry on CaGene 4.3 software
Manchester Hand calculations Male and female breast, ovarian, prostate and pancreatic cancer Excludes Ashkenazi Jewish 1st, 2nd, and 3rd degree relatives Scoring system
Penn II Web-based Male and female breast, ovarian, prostate and pancreatic cancer Excludes probands from families with no breast cancer cases 1st, 2nd, and 3rd degree relatives One page questionnaire
IBIS Down-loadable software Female breast and ovarian cancer Includes only females unaffected by breast cancer 1st, 2nd, and 3rd degree relatives One page questionnaire
BOADICEA Web-based Breast, ovarian, prostate and pancreatic cancer All individuals 1st, 2nd, and 3rd degree relatives Complete pedigree data entered for affected and unaffected