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Table 2 Haplotype analysis of SNPs from the IL10 gene cluster with major depressive disorder.

From: Polymorphisms in the interleukin-10 gene cluster are possibly involved in the increased risk for major depressive disorder

 

Controls

(n = 277)

Patients

(n = 153)

P-value nom

P-value adj

OR (95% CI)

Block 1 haplotypes (IL19 and IL20 genes)

CGT

68.6

67.3

0.7093

1.0000

0.94 (0.69–1.28)

AAG

17.9

21.4

0.2297

0.8840

1.25 (0.87–1.79)

CGG

10.1

8.4

0.4168

0.9890

0.81 (0.49–1.35)

CAG

2.3

1.1

0.2506

0.9180

0.49 (0.14–1.68)

Block 2 haplotypes (IL20 and IL24 genes)

CGT

53.3

51.6

0.6459

1.0000

0.94 (0.70–1.25)

TAC

42.8

40.8

0.5768

1.0000

0.92 (0.69–1.23)

CAT

1.9

2.8

0.4109

0.9890

1.47 (0.58–3.74)

TGC

1.2

3.9

0.0097

0.0420

3.45 (1.28–9.32)

  1. P-values ≤ 0.05 are in bold; P-value nom: nominal P-value; P-value adj: permutation adjusted P-value; OR: odds ratio; CI: confidence interval
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BMC Medical Genetics

ISSN: 1471-2350

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