Table 1 Distribution of the GABRE 3 mutation (Ser102Ala), GABRE 5 mutation (Ala 193Ala), in migraineurs and controls of original sample (MO migraine without aura, MA migraine with aura).
From: Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility
| Â | N | Alleles | Â | Â | Genotypes | Â |
|---|---|---|---|---|---|---|
Group | (alleles) | G | T | GG | GT | TT |
GABRE3 SNP | rs 2050843 | Â | Â | Â | Â | Â |
Migraine | 384 | 282 (73.4%) | 102 (26.6%) | 114 (59.4%) | 54 (28.1%) | 24(12.5%) |
Male | 112 | 84 (75%) | 28 (25%) | Â | Â | Â |
Female | 272 | 198 (73%) | 74 (27%) | 72 (53%) | 54 (39.7%) | 10 (7.3%) |
MA | 254 | 194 (76.4%) | 60 (23.6%) | 77 (60.6%) | 40 (31.5%) | 10 (7.9%) |
MO | 130 | 88 (67.7%) | 42 (32.3%) | 37 (57%) | 14 (21.5%) | 14 (21.5%) |
Control | 374 | 285 (76.2%) | 89 (23.8%) | 119 (63.6%) | 47 (25.2%) | 21 (11.2%) |
Male | 90 | 60 (67%) | 30 (33%) | Â | Â | Â |
Female | 284 | 225 (79.2%) | 59 (20.8%) | 89 (62.6%) | 47 (33%) | 6 (4.4%) |
Total case vs control | Â | X2 = 0.33 | P = 0.56 | Â | X2 = 0.73 | P = 0.695 |
Subtype MA vs cont: | Â | X2 = 0.00 | P = 0.99 | Â | X2 = 2.08 | P = 0.35 |
Subtype MO vs cont | Â | X2 = 3.63 | P = 0.06 | Â | X2 = 4.3 | P = 0.11 |
| Â | N | Alleles | Â | Â | Genotypes | Â |
Group | (alleles) | T | C | TT | TC | CC |
GABRE5 SNP | rs 2256882 | Â | Â | Â | Â | Â |
Migraine | 332 | 34 (10.3%) | 298 (89.7%) | 6 (3.4%) | 22 (12.4%) | 149 (84.2%) |
Male | 92 | 10 (10.9%) | 82 (89.1%) | Â | Â | Â |
Female | 262 | 24 (9.2%) | 238 (90.8%) | 1 (0.8%) | 22 (16.8%) | 108 (82.4%) |
MA | 204 | 19 (9.3%) | 185 (90.7%) | 3 (2.9%) | 13 (12.8%) | 86 (84.3%) |
MO | 152 | 16 (10.5%) | 136 (89.5%) | 3 (3.9%) | 10 (13.2%) | 63 (82.9%) |
Control | 374 | 45 (12%) | 329 (88%) | 10 (5.3%) | 25 (13.4%) | 152 (81.3%) |
Male | 104 | 12 (11.5%) | 92 (88.5%) | Â | Â | Â |
Female | 270 | 33 (12.2%) | 237 (87.8%) | 4 (3%) | 25 (18.5%) | 106 (78.5%) |
Total case vs control | Â | X2 = 0.57 | P = 0.45 | Â | X2 = 0.95 | P = 0.62 |
Subtype MA vs cont: | Â | X2 = 0.99 | P = 0.32 | Â | X2 = 0.94 | P = 0.62 |
Subtype MO vs cont | Â | X2 = 0.24 | P = 0.62 | Â | X2 = 0.23 | P = 0.89 |
| Â | N | Alleles | Â | Â | Genotypes | Â |
Group | (alleles) | T | C | TT | TC | CC |
GABRE9 SNP | Â | Â | Â | Â | Â | Â |
Migraine | 316 | 20 (6.3%) | 296 (93.7%) | 7 (4.4%) | 6 (3.8%) | 145 (91.8%) |
Male | 88 | 6 (6.8%) | 82 (93.2%) | Â | Â | Â |
Female | 228 | 14 (6.1%) | 214 (93.9%) | 4 (3.5%) | 6 (5.3%) | 104 (91.2%) |
MA | 198 | 9 (4.5%) | 189 (95.5%) | 3 (3%) | 3 (3%) | 93 (94%) |
MO | 118 | 11 (9.3%) | 107 (90.7%) | 4 (6.8%) | 3 (5.1%) | 52 (88.1%) |
Control | 280 | 23 (8.2%) | 257 (91.8%) | 7 (5%) | 9 (6.4%) | 124 (88.6%) |
Male | 80 | 4 (5%) | 76 (95%) | Â | Â | Â |
Female | 200 | 19 (9.5%) | 181 (90.5%) | 5 (5%) | 9 (9%) | 86 (86%) |
Total case vs control | Â | X2 = 0.79 | P = 0.37 | Â | X2 = 1.16 | P = 0.56 |
Subtype MA vs cont: | Â | X2 = 2.50 | P = 0.11 | Â | X2 = 2.06 | P = 0.36 |
Subtype MO vs cont | Â | X2 = 0.13 | P = 0.72 | Â | X2 = 0.36 | P = 0.83 |