Table 1 Detailed analysis for rs6330, genotyped in 1120 and 869 controls.
From: Genomic NGFBvariation and multiple sclerosis in a case control study
Genotype (%) | p value | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SNP (maj./min. allele) | cohort | Stratif-ication | Maj. allele (%) | Min. allele (%) | p value | OR (CI*1) | XX | Xx | xx | Geno-type | Major allel dominant | co-dominant | Minor allele dominant | HWE p value | N |
rs6330 (C/T) | MS | Ø | 1235 (57.2) | 923 (42.8) | 0.0038 | 1.210 (1.063–1.377) | 356 (33.0) | 523 (48.5) | 200 (18.5) | 0.0126 | 0.0579 | 0.3034 | 0.0056 | 0.75 | 1079 |
male | 438 (59.8) | 294 (40.2) | 0.0087 | 1.308 (1.070–1.599) | 133 (36.3) | 172 (47.0) | 61 (16.7) | 0.0247 | 0.1109 | 0.2403 | 0.0091 | 0.67 | 366 | ||
female | 797 (55.9) | 629 (44.1) | 0.0598 | 1.149 (0.946–1.395) | 223 (31.3) | 351 (49.2) | 139 (19.5) | 0.1672 | 0.1665 | 0.6840 | 0.0938 | 0.97 | 713 | ||
rr Ø | 677 (56.9) | 513 (43.1) | 0.0211 | 1.193 (1.015–1.210) | 192 (32.3) | 293 (49.2) | 110 (18.5) | 0.0647 | 0.1011 | 0.5493 | 0.0345 | 0.92 | 595 | ||
rr male | 240 (61.2) | 152 (38.8) | 0.0087 | 1.386 (1.086–1.770) | 75 (38.3) | 90 (45.9) | 31 (15.8) | 0.0230 | 0.1196 | 0.2226 | 0.0081 | 0.65 | 196 | ||
rr female | 437 (54.8) | 361 (45.2) | 0.2276 | 1.098 (0.885–1.361) | 117 (29.3) | 203 (50.9) | 79 (19.8) | 0.4648 | 0.2701 | 0.9151 | 0.3737 | 0.59 | 399 | ||
sp Ø | 271 (56.5) | 209 (43.5) | 0.1276 | 1.173 (0.955–1.439) | 78 (32.5) | 115 (47.9) | 47 (19.6) | 0.2503 | 0.4119 | 0.4231 | 0.1016 | 0.69 | 240 | ||
sp male | 73 (55.3) | 59 (44.7) | 0.6597 | 1.086 (0.752–1.569) | 21 (31.8) | 31 (47.0) | 14 (21.2) | 0.7583 | 0.9914 | 0.5229 | 0.4839 | 0.69 | 66 | ||
sp female | 198 (56.9) | 150 (43.1) | 0.1082 | 1.197 (0.915–1.565) | 57 (32.8) | 84 (48.3) | 33 (19.0) | 0.2593 | 0.2818 | 0.6243 | 0.1264 | 0.84 | 174 | ||
pp Ø | 287 (58.8) | 201 (41.2) | 0.0143 | 1.291 (1.052–1.584) | 86 (35.2) | 115 (47.1) | 43 (17.6) | 0.0369 | 0.1358 | 0.3070 | 0.0137 | 0.67 | 244 | ||
pp male | 125 (60.1) | 83 (39.9) | 0.0759 | 1.322 (0.971–1.800) | 37 (35.6) | 51 (49.0) | 16 (15.4) | 0.1967 | 0.1883 | 0.6930 | 0.1116 | 0.82 | 104 | ||
pp female | 162 (57.9) | 118 (42.1) | 0.0779 | 1.245 (0.933–1.660) | 49 (35.0) | 64 (45.7) | 27 (19.3) | 0.1540 | 0.3615 | 0.3297 | 0.0557 | 0.46 | 140 | ||
control | Ø | 857 (52.5) | 775 (47.5) | 221 (27.1) | 415 (50.9) | 180 (22.1) | 0.57 | 816 | |||||||
male | 443 (53.2) | 389 (46.8) | 115 (27.6) | 213 (51.2) | 88 (21.2) | 0.56 | 416 | ||||||||
female | 414 (51.7) | 386 (48.3) | 106 (26.5) | 202 (50.5) | 92 (23.0) | 0.82 | 400 | ||||||||