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Figure 5 | BMC Medical Genetics

Figure 5

From: A novel RUNX2 missense mutation predicted to disrupt DNA binding causes cleidocranial dysplasia in a large Chinese family with hyperplastic nails

Figure 5

A) Comparison of sequences in the vicinity of RUNX2 L136 (arrow) from various species. B) The RUNX1 Runt domain-CBFβ-DNA complex showing the location of L136 (green). The Runt domain is grey, CBFβ is purple, and the DNA is yellow and orange. Side chains of the DNA contacting residues R131 and K134 in the βA'-B loop are also shown.

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BMC Medical Genetics

ISSN: 1471-2350

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