From: The intron 4c allele of the NOS3 gene is associated with ischemic stroke in African Americans
Risk factors | Overall | Caucasian | African American | |
---|---|---|---|---|
Crude O.R. of intron 4 VNTR (cc+ac+bc vs. aa+ab+bb) | 3.84 (1.21 – 12.14), p = 0.02 | 1.64 (0.23 – 11.70), p = 0.62 | 4.33 (0.86 – 21.77), p = 0.08 | |
Adjusted O.R. | c allele of intron 4 VNTR (cc+ac+bc vs. aa+ab+bb) | 3.54 (1.08 – 11.60), p = 0.04 | 1.48 (0.20 – 10.96), p = 0.70 | 5.06 (0.81 – 31.53), p = 0.08 |
 | Age | 1.02 (1.01 – 1.03), p < 0.01 | 1.03 (1.01 – 1.04), p < 0.01 | 1.03 (0.99 – 1.07), p = 0.14 |
 | Gender | 1.45 (1.09 – 1.93), p < 0.05 | 1.46 (1.05 – 2.04), p < 0.05 | 1.13 (0.38 – 3.42), p = 0.82 |
 | Hypertension | 1.99 (1.44 – 2.75), p < 0.01 | 1.68 (1.15 – 2.45), p < 0.01 | 2.75 (0.88 – 8.64), p = 0.09 |
 | Diabetes | 1.56 (1.14 – 2.12), p < 0.01 | 1.38 (0.96 – 1.99), p = 0.08 | 2.34 (0.81 – 6.75), p = 0.12 |
Crude O.R. of Glu298Asp (TT+GT vs. GG) | 1.10 (0.81 – 1.49), p = 0.55 | 1.11(0.78 – 1.58), p = 0.56 | 2.25 (0.80 – 6.35), p = 0.13 | |
Adjusted O.R. | T allele of Glu298Asp (TT + GT vs. GG) | 1.11 (0.81 – 1.53), p = 0.51 | 1.12 (0.78 – 1.61), p = 0.55 | 2.84 (0.79 – 10.14), p = 0.11 |
 | Age | 1.01 (0.99 – 1.02), p = 0.06 | 1.02 (1.01 – 1.04), p < 0.05 | 1.04 (0.99 – 1.08), p = 0.09 |
 | Gender | 1.39 (1.01 – 1.91), p = 0.05 | 1.44 (0.99 – 2.08), p = 0.05 | 1.10 (0.34 – 3.55), p = 0.87 |
 | Hypertension | 1.96 (1.37 – 2.81), p < 0.01 | 1.65 (1.08 – 2.50), p < 0.05 | 2.72 (0.72 – 10.28), p = 0.14 |
 | Diabetes | 1.54 (1.08 – 2.18), p < 0.05 | 1.41(0.93 – 2.13), p = 0.10 | 2.15 (0.59 – 7.90), p = 0.25 |