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Table 3 Crude and adjusted odd ratios for stroke risk factors and gene in logistic regression analysis.

From: The intron 4c allele of the NOS3 gene is associated with ischemic stroke in African Americans

Risk factors

Overall

Caucasian

African American

Crude O.R. of intron 4 VNTR (cc+ac+bc vs. aa+ab+bb)

3.84 (1.21 – 12.14), p = 0.02

1.64 (0.23 – 11.70), p = 0.62

4.33 (0.86 – 21.77), p = 0.08

Adjusted O.R.

c allele of intron 4 VNTR (cc+ac+bc vs. aa+ab+bb)

3.54 (1.08 – 11.60), p = 0.04

1.48 (0.20 – 10.96), p = 0.70

5.06 (0.81 – 31.53), p = 0.08

 

Age

1.02 (1.01 – 1.03), p < 0.01

1.03 (1.01 – 1.04), p < 0.01

1.03 (0.99 – 1.07), p = 0.14

 

Gender

1.45 (1.09 – 1.93), p < 0.05

1.46 (1.05 – 2.04), p < 0.05

1.13 (0.38 – 3.42), p = 0.82

 

Hypertension

1.99 (1.44 – 2.75), p < 0.01

1.68 (1.15 – 2.45), p < 0.01

2.75 (0.88 – 8.64), p = 0.09

 

Diabetes

1.56 (1.14 – 2.12), p < 0.01

1.38 (0.96 – 1.99), p = 0.08

2.34 (0.81 – 6.75), p = 0.12

Crude O.R. of Glu298Asp (TT+GT vs. GG)

1.10 (0.81 – 1.49), p = 0.55

1.11(0.78 – 1.58), p = 0.56

2.25 (0.80 – 6.35), p = 0.13

Adjusted O.R.

T allele of Glu298Asp (TT + GT vs. GG)

1.11 (0.81 – 1.53), p = 0.51

1.12 (0.78 – 1.61), p = 0.55

2.84 (0.79 – 10.14), p = 0.11

 

Age

1.01 (0.99 – 1.02), p = 0.06

1.02 (1.01 – 1.04), p < 0.05

1.04 (0.99 – 1.08), p = 0.09

 

Gender

1.39 (1.01 – 1.91), p = 0.05

1.44 (0.99 – 2.08), p = 0.05

1.10 (0.34 – 3.55), p = 0.87

 

Hypertension

1.96 (1.37 – 2.81), p < 0.01

1.65 (1.08 – 2.50), p < 0.05

2.72 (0.72 – 10.28), p = 0.14

 

Diabetes

1.54 (1.08 – 2.18), p < 0.05

1.41(0.93 – 2.13), p = 0.10

2.15 (0.59 – 7.90), p = 0.25

  1. The 95% confidence interval of odds ratio (O.R.) was expressed in parentheses.