Table 2 Allele frequencies of candidate genes among each stroke subtype.
From: The intron 4c allele of the NOS3 gene is associated with ischemic stroke in African Americans
Gene | Races | Allele | Controls 2n (%) | All Cases 2n (%) | TOAST classification, 2n (%) | |||
|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Â | Â | Large artery atherosclerosis | Small vessel occlusion | Cardio- embolism | Others |
Intron 4 VNTR | All | b | 830 (83.2) | 590 (80.6) | 186 (78.2) | 142 (80.7) | 145 (83.3) | 117 (81.3) |
| Â | Â | a | 164 (16.4) | 127 (17.3) | 40 (16.8) | 34 (19.3) | 27 (15.5) | 26 (18.1) |
|  |  | c | 4 (0.4) | 15 (2.0) †| 12 (5.0) †| 0 (0.0) | 2 (1.1) | 1 (0.7) |
| Â | Caucasian | b | 688 (84.3) | 410 (82.0) | 129 (81.6) | 100 (80.6) | 112 (82.4) | 69 (84.1) |
| Â | Â | a | 126 (15.4) | 87 (17.4) | 26 (16.5) | 24 (19.4) | 24 (17.6) | 13 (15.9) |
| Â | Â | c | 2 (0.2) | 3 (0.6) | 3 (1.9) * | 0 (0.0) | 0 (0.0) | 0 (0.0) |
| Â | African American | b | 57 (69.5) | 57 (64.8) | 13 (46.4) | 12 (75.0) | 16 (80.0) | 16 (66.7) |
| Â | Â | a | 23 (28.0) | 20 (22.7) | 7 (25.0) | 4 (25.0) | 2 (10.0) | 7 (29.2) |
|  |  | c | 2 (2.4) | 11 (12.5) * | 8 (28.6) †| 0 (0.0) | 2 (10.0) | 1 (4.2) |
Glu298Asp | All | G | 482 (70.9) | 460 (70.3) | 151 (71.2) | 111 (72.1) | 99 (64.3) | 99 (73.9) |
| Â | Â | T | 198 (29.1) | 194 (29.7) | 61 (28.8) | 43 (27.9) | 55 (35.7) | 35 (26.1) |
| Â | Caucasian | G | 392 (68.8) | 303 (67.6) | 98 (67.1) | 74 (69.8) | 74 (61.7) | 57 (75.0) |
| Â | Â | T | 178 (31.2) | 145 (32.4) | 48 (32.9) | 32 (30.2) | 46 (38.3) | 19 (25.0) |
| Â | African American | G | 44 (84.6) | 59 (73.8) | 20 (83.3) | 13 (81.2) | 10 (62.5) | 16 (66.7) |
| Â | Â | T | 8 (15.4) | 21 (26.2) | 4 (16.7) | 3 (18.8) | 6 (37.5) | 8 (33.3) |