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Figure 2 | BMC Medical Genetics

Figure 2

From: A comprehensive analysis of common genetic variation in prolactin (PRL) and PRL receptor (PRLR) genes in relation to plasma prolactin levels and breast cancer risk: the Multiethnic Cohort

Figure 2

Linkage disequilibrium (LD) plot across the prolactin receptor (PRLR) locus for all racial/ethnic groups combined. The horizontal black line depicts the 210-kilobase region of chromosome (chr) 5 analyzed in our multiethnic panel. The PRLR gene is shown in grey (RefSeq gene = completed genes from the human genome assembly). Alternative first exons are shown in black below the gene: hE13, hE1N1, hE1N2, hE1N3, hE1N4, and hE1N5. The 173 single nucleotide polymorphisms (SNPs) used for genetic characterization are listed below the black line. The LD plot, presented at the bottom of the figures, is based on the measure of D'. Each diamond indicates the pairwise magnitude of LD, with dark grey indicating strong LD (D' > 0.8) and a logarithm of odds score of greater than 2.0. (Figure prepared with LocusView, Broad Institute, Cambridge, MA, unpublished software by T. Petryshen, A. Kirby, and M. Ainscow [61]).

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