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Table 1 Summary of the NOTCH3 mutations detected in our CADASIL families

From: CADASIL in Arabs: clinical and genetic findings

Family Ethnicity Mutation detected Exon Amino acid change Domain Frequency in our controls (n= 100)
A Saudi c.406C>T 3 p.Arg110>Cys EGF2 ND
B Kuwait c.406C>T 3 p.Arg110>Cys EGF2 ND
C Yemen c.475 C>T 4 p.Arg133>Cys EGF3 ND
  1. EGF = Epidermal Growth Factor Like Repeats.
  2. ND = not detected