Analysis of KLFtranscription factor family gene variants in type 2 diabetes

Gutiérrez-Aguilar, Ruth; Benmezroua, Yamina; Vaillant, Emmanuel; Balkau, Beverley; Marre, Michel; Charpentier, Guillaume; Sladek, Rob; Froguel, Philippe; Neve, Bernadette

doi:10.1186/1471-2350-8-53

BMC Medical Genetics

Table 2 Genotypic distribution of KLF SNPs in type 2 diabetic and non-diabetic individuals

From: Analysis of KLFtranscription factor family gene variants in type 2 diabetes

dbSNP ID	N/M	MAF D1/C1	P-value	MAF D2/C2	P-value	MAF D/C	P-value
KLF2, Chr. 19q13		0.31 (167, 142, 34)	0.69
Prom -789	C/T	0.32 (148, 143, 30)
rs10424657	G/A	0.30 (175, 146, 34)	0.61
		0.31 (162, 155, 32)
rs12459387	C/T	0.09 (292, 58, 4)	0.09	0.10 (464, 106, 6)	0.87	0.10 (756, 164, 10)	0.40
		0.12 (260, 78, 2)		0.10 (543, 123, 6)		0.11 (803, 201, 8)
rs7248864	C/T	0.09 (295, 56, 5)	0.13
		0.12 (270, 78, 2)
rs3745318	C/T	0.21 (211, 109, 16)	0.67
		0.20 (214, 114, 11)
rs12462380	A/G	0.41 (119, 178, 56)	0.24
		0.44 (102, 170, 63)
rs7258799	A/T	0.13 (277, 81, 6)	0.15
		0.16 (219, 74, 10)
rs15336	C/A	0.19 (235, 111, 12)	0.21
		0.16 (235, 94, 8)
rs11086029	A/T	0.22 (209, 121, 14)	0.63
		0.21 (217, 117, 13)
KLF3, Chr. 4q14		0.44 (110, 180, 70)	0.89
rs2045767	G/T	0.45 (105, 182, 68)
rs9522	C/T	0.45 (110, 171, 75)	0.62
		0.46 (97, 178, 72)
KLF4, Chr. 9q31		0.47 (97, 174, 79)	0.08	0.49 (144, 297, 133)	0.68	0.48 (241, 471, 212)	0.08
rs10759240	C/A	0.52 (80, 168, 95)		0.51 (176, 361, 187)		0.51 (256, 529, 282)
KLF5, Chr. 13q21		0.16 (248, 97, 6)	0.67
rs12428414	C/T	0.16 (237, 88, 11)
rs4885065	A/G	0.17 (245, 94, 11)	0.83
		0.16 (247, 98, 8)
rs9564944	A/G	0.12 (263, 69, 5)	0.90
		0.12 (269, 62, 8)
rs11841945	C/G	0.46 (94, 173, 65)	0.04	0.42 (200, 271, 110)	0.20	0.43 (294, 444, 175)	0.91
		0.40 (110, 145, 48)		0.45 (227, 349, 151)		0.43 (337, 494, 199)
KLF6, Chr. 10p15		0.11 (290, 68, 5)	0.63
rs7005	C/T	0.12 (281, 66, 8)
KLF12, Chr. 13q21		0.36 (148, 164, 47)	0.36
rs1927010	A/T	0.32 (154, 162, 38)
rs4885151	G/T	0.31 (165, 166, 31)	0.80
		0.32 (169, 144, 42)
rs7993625	C/T	0.24 (205, 128, 21)	0.60
		0.23 (199, 133, 12)
rs6650443	A/G	0.19 (245, 99, 19)	0.66
		0.20 (224, 107, 15)
rs9600167	C/G	0.35 (154, 158, 46)	0.49
		0.23 (160, 141, 44)
KLF13, Chr. 15q12		0.44 (120, 169, 74)	0.71
rs11855557	A/G	0.45 (102, 189, 64)
rs12592176	G/A	0.50 (84, 186, 83)	0.49
		0.48 (98, 172, 84)
rs4779516	T/C	0.44 (115, 175, 70)	0.36
		0.46 (96, 187, 69)
KLF15, Chr. 3q13		0.12 (268, 74, 4)	0.35
3'UTR+244del(CACGAAGG)		0.10 (285, 58, 7)
KLF16, Chr. 19q13		0.47 (100, 162, 79)	0.11
rs11670146	A/G	0.47 (101, 144, 56)
rs3746045	T/C	0.24 (208, 120, 24)	0.23
		0.21 (214, 119, 14)

D, type 2 diabetic patients; C, non-diabetic individuals; MAF, minor allele frequency; (number of subjects with wild type homozygote; heterozygote; mutant homozygote alleles); P-value for differences between allele frequencies under an allelic model.

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