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Figure 6 | BMC Medical Genetics

Figure 6

From: Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging

Figure 6

Liver and kidney methylation. A: Tag methylation with chronological aging in the liver. The trend line indicates an age-related increase in methylation, but the data were not significantly different from a level line (p = 0.38 for CSX, p = 0.19 for SOX10, linear regression). Red solid dots indicate the two samples with cirrhosis. Tag methylation was significantly greater in adults (black bars, N = 80 and 72 alleles for CSX and SOX10 tags) compared to younger individuals ≤ 5 years of age (gray bars, N = 32 alleles for CSX and SOX10 tags). B: Tag methylation with chronological aging in the kidney. The trend line indicates an age-related increase in methylation, but the data were not significantly different from a level line (p = 0.59 for CSX, p = 0.097 for SOX10). Red solid dots indicate samples with benign nephrosclerosis. Tag methylation was significantly greater in adults (black bars, N = 105 and 104 alleles for CSX and SOX10 tags) compared to younger individuals ≤ 5 years of age (gray bars, N = 40 alleles for CSX and SOX10 tags).

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BMC Medical Genetics

ISSN: 1471-2350

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