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Figure 3 | BMC Medical Genetics

Figure 3

From: Lack of increases in methylation at three CpG-rich genomic loci in non-mitotic adult tissues during aging

Figure 3

Simulations of random methylation errors at the CSX and SOX10 tags. For CSX tags, the simulated error rates are 1 × 10-4 per CpG site per division for methylation and 2 × 10-5 for demethylation. SOX10 tags appear to become methylated faster in human tissues, and the simulated error rate for methylation is greater (1 × 10-3) with the same demethylation error rate as CSX. Errors are assumed to be independent between CpG sites, and each tag is an independent genome (no shared ancestry). These simulations are presented to illustrate the general stochastic nature of mutation, and are not an attempt to model the experimental data. A: Frequencies of individual tag methylation values and averages of 8 tags after 500 (green), 1,000 (red), 2,000 (blue), or 5,000 (gray) simulated divisions. As expected, values are more scattered for individual versus average tag values. B: Examples of simulated individual CSX or SOX10 tags after different numbers of divisions.

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