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Figure 3 | BMC Medical Genetics

Figure 3

From: Dominant inhibition of Fas ligand-mediated apoptosis due to a heterozygous mutation associated with autoimmune lymphoproliferative syndrome (ALPS) Type Ib

Figure 3

Fas-mediated T-cell apoptosis in Family 86. The percentage of T cells killed by the treatment with an agonistic anti-Fas antibody is shown for the patient, members of his extended family, a normal control, and an ALPS Type Ia patient with a mutation in the Fas death domain. Percent cell loss is calculated as (1-number of cells with antibody stimulation/number of cells without stimulation) 100%. One representative of three repeated experiments is shown.

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