Evidence for association between the HLA-DQA locus and abdominal aortic aneurysms in the Belgian population: a case control study

Table 9 Previous HLA studies on AAA

Study	Country	n (Inflammatory AAA)^a	HLA locus studied	Significant allele^b	p
Norrgård et al 1984 [11]	Sweden	48	HLA-A, -B^c	None	N/A
Tilson et al 1996 [12]	US	26	HLA-DRB1	DRB1*02	0.04
				DRB1*12	0.02
Rasmussen et al 1997 [13]	US	37	HLA-DQB1, DRB1	DRB1*15	<0.05
		(37)		DRB1*0404	<0.05
Hirose et al 1998 [14]	Japan	46	HLA-DR^c	DR2(15)	<0.005
Hirose & Tilson 1999 [15]	Japan	36	HLA-DQ^c	DQ3	0.014
Rasmussen et al 2001 [16]	US	142	HLA-DRB1	DRB1*02	0.03
		(40)			0.01^d
Rasmussen et al 2002 [17]	US	142	HLA-DRB1	DRB1*02	<0.01
				DRB1*08	0.04
				DRB1*14	<0.01
Sugimoto et al 2003 [18]	Japan	49	HLA-A, -B, -DR	A2	<0.05
				B61	<0.005
Moňux et al 2003 [19]	Spain	72	HLA-DRB1	DRB1*0401	0.02

AAA: abdominal aortic aneurysm.
^a Inflammatory AAA was categorized and analyzed separately.
^b Allele which had a significantly different frequency between AAA cases and controls.
^c Serological typing was carried out.
^d P-value for inflammatory AAA.

ISSN: 1471-2350