An investigation of polymorphisms in the 17q11.2-12 CC chemokine gene cluster for association with multiple sclerosis in Australians

Table 3 Single locus TDT analysis of individually genotyped CC chemokine gene markers.

Locus	All families		HLA-DRB1*1501 positive		HLA-DRB1*1501 negative		RR-MS		SP-MS		Male		Female
	T:N	P	T:N	P	T:N	P	T:N	P	T:N	P	T:N	P	T:N	P
*CCL2 -2581A>G	79:89	0.4	48:57	0.4	31:32	0.9	51:68	0.1	21:16	0.4	16:13	0.60	63:76	0.3
*CCL2 -2138A>T	56:75	0.1	35:41	0.5	21:34	0.08	41:56	0.1	12:15	0.6	13:13	1	43:62	0.06
CCL11 -488C>A	88:96	0.6	45:59	0.2	43:37	0.5	68:69	0.9	15:17	0.7	20:22	0.8	68:74	0.6
*CCL11 67G>A	71:65	0.6	39:37	0.8	32:28	0.6	54:46	0.4	14:13	0.8	15:15	1	56:50	0.6
CCL8 -572C>T	143:127	0.3	84:78	0.6	59:49	0.3	107:96	0.4	23:22	0.9	28:32	0.6	115:95	0.2
*CCL5 -471C>T	64:70	0.6	45:35	0.3	19:35	0.03	47:50	0.8	14:13	0.9	14:18	0.5	50:52	0.8
CCL16 -595C>A	103:91	0.4	58:53	0.6	45:38	0.4	76:66	0.4	14:19	0.4	19:19	1	84:72	0.3
CCL14 -649T>A	100:88	0.4	64:49	0.2	36:39	0.7	81:56	0.03	9:22	0.02	17:21	0.5	83:67	0.2
*CCL15 136+88C>T	18:10	0.1	11:6	0.2	7:4	0.4	15:6	0.05	2:3	0.7	2:3	0.7	16:7	0.06
*CCL15 -1284A>C	29:27	0.8	21:20	0.9	8:7	0.8	25:17	0.2	2:5	0.3	3:6	0.3	26:21	0.5
CCL23 316T>C	85:90	0.7	54:57	0.8	31:33	0.8	70:58	0.3	8:21	0.02	13:22	0.1	72:68	0.7
*CCL23 -289A>C	62:71	0.4	42:42	1	20:29	0.2	51:46	0.6	9:17	0.1	8:19	0.03	54:52	0.9

T:N = Transmitted:Non-transmitted for major allele
*Markers genotyped using SNaPshot in 204 trio families; HLA-DRB1*1501 positive: 123 trio families; HLA-DRB1*1501 negative: 81 trio families; RR-MS: 147 trio families; SP-MS: 42 trio families; Male: 38 trio families; Female: 166 trio families Remaining markers genotyped using SNPlex™; All families: 269–296 trio families; HLA-DRB1*1501 positive: 156–176 trio families; HLA-DRB1*1501 negative: 113–120 trio families; RR-MS: 193–218 trio families; SP-MS: 52–56 trio families; Male: 53–60 trio families; Female: 216–236 trio families. Significant P values in bold. P values are not corrected for multiple comparisons.

ISSN: 1471-2350