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Table 1 Summary of SNPs identified by sequencing of CC chemokine genes in DNA pools that were selected for individual genotyping. Other detected SNPs are described in Supplementary Table 2.

From: An investigation of polymorphisms in the 17q11.2-12 CC chemokine gene cluster for association with multiple sclerosis in Australians

  

Estimated minor allele frequency

Estimated relative risk

(for minor allele frequency >0.15)

Locus

rsID

Control pool

HLA-DRB1*1501

positive pool

HLA-DRB1*1501

negative pool

Familial pool

CCL2

     

   -2581A>G

1024611

0.5

0.9

0.8

0.7

   -2138A>T

1024610

0.3

1.2

1.5

1.5

CCL11

     

   -488C>A

17735961

0.2

1.2

1.2

1.3

   67G>A (A>T) +

3744508

0.1

-

-

-

CCL8

     

   -572C>T

3138035

0.3

1.1

1.0

1.2

   † 205A>C (K>Q)+

3138038

0.2

0.8

0.8

0.7

CCL5 (-)

     

   -471C>T

2107538

0.2

1.2

1.3

1.1

CCL16 (-)

     

   -595C>A

854680

0.1

-

-

-

CCL14 (-)

     

   -649T>A

854682

0.2*

1.1*

1.0*

1.4*

CCL15 (-)

     

   -1284A>C

854628

<0.1

-

Undetectable

-

   136+88C>T

Novel

0.3

0.8

0.6

0.5

CCL23 (-)

     

   -289A>C

854655

0.2*

0.7*

0.5*

1.0*

   316T>C (M>V)+

1003645

0.2*

1.0*

0.7*

1.0*

  1. All SNPs classified relative to translation start site. Relative risks determined relative to control pool. SNPs in bold were individually genotyped in second stage
  2. (-) Gene encoded in anti-sense direction; SNPs reclassified to account for this
  3. + Coding change in brackets
  4. †The CCL8 205 SNP was originally selected for genotyping by SNPLEX™, but failed the SNPLEX™ algorithm, and was replaced with the CCL8 -572 SNP
  5. * Heterozygous individual correction applied
  6. rsID: SNP identification number
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BMC Medical Genetics

ISSN: 1471-2350

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