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Table 2 Phenotypic frequencies (carriership) of the three-allele combinations (trios) and their two-element subsets in Russian MS patients and healthy individuals

From: Three allele combinations associated with Multiple Sclerosis

Allelic combinations MS patients, N (%) Controls, N (%) p-value# OR (95% CI)##
-509TGFβ1*C, DRB1*18(3), CTLA4*G (trio 1)* 5 (5.3) 0 (0) 0.0086 18.0 (1.0–330)
-509TGFβ1*C, DRB1*18(3) 5 (4.4) 2 (0.7) 0.029  
-509TGFβ1*C, CTLA4*G 63 (61) 102 (58) 0.61  
DRB1*18(3), CTLA4*G 5 (3.0) 2 (1.1) 0.26  
-238TNF*B1,-308TNF*A2, CTLA4*G (trio 2)** 11 (8.7) 0 (0) 0.0033 17.4 (1.1–300)
-238TNF*B1,-308TNF*A2 13 (9.9) 6 (5.4) 0.26  
-238TNF*B1, CTLA4*G 38 (30) 15 (17) 0.036  
-308TNF*A2, CTLA4*G 26 (16) 15 (14) 0.73  
  1. * 99 MS patients and 154 controls were genotyped at these polymorphic loci of TGFβ1, DRB1 and CTLA4 genes.
  2. ** 126 MS patients and 87 controls were genotyped at these polymorphic loci of TNF and CTLA4 genes.
  3. # p-values considered to be significant are given in bold face.
  4. ## OR (95% CI) values are shown for significant p-values.