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Table 2 Phenotypic frequencies (carriership) of the three-allele combinations (trios) and their two-element subsets in Russian MS patients and healthy individuals

From: Three allele combinations associated with Multiple Sclerosis

Allelic combinations

MS patients, N (%)

Controls, N (%)

p-value#

OR (95% CI)##

-509TGFβ1*C, DRB1*18(3), CTLA4*G (trio 1)*

5 (5.3)

0 (0)

0.0086

18.0 (1.0–330)

-509TGFβ1*C, DRB1*18(3)

5 (4.4)

2 (0.7)

0.029

 

-509TGFβ1*C, CTLA4*G

63 (61)

102 (58)

0.61

 

DRB1*18(3), CTLA4*G

5 (3.0)

2 (1.1)

0.26

 

-238TNF*B1,-308TNF*A2, CTLA4*G (trio 2)**

11 (8.7)

0 (0)

0.0033

17.4 (1.1–300)

-238TNF*B1,-308TNF*A2

13 (9.9)

6 (5.4)

0.26

 

-238TNF*B1, CTLA4*G

38 (30)

15 (17)

0.036

 

-308TNF*A2, CTLA4*G

26 (16)

15 (14)

0.73

 
  1. * 99 MS patients and 154 controls were genotyped at these polymorphic loci of TGFβ1, DRB1 and CTLA4 genes.
  2. ** 126 MS patients and 87 controls were genotyped at these polymorphic loci of TNF and CTLA4 genes.
  3. # p-values considered to be significant are given in bold face.
  4. ## OR (95% CI) values are shown for significant p-values.
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BMC Medical Genetics

ISSN: 1471-2350

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